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Recombinant Mouse Pdgfra, GST-tagged, Active

Cat. No. : Pdgfra-385M
Product Overview : Recombinant Mouse full-length Pdgfra (550-end) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=100 kDa.
Description : PDGFRα (platelet-derived growth factor receptor α) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFRα has been linked to developmental abnormalities in vertebrate models and has been implicated in multiple disease states in humans. There is widespread expression of PDGFRα in renal cell types involved in fibrotic and sclerosing processes. PDGF and its receptor PDGFRα are inducers of fibrosis in the repair phase of inflammatory bowel disease and they may also be involved in the active inflammatory phase.
Source : Sf9 insect cells using baculovirus.
Sequence : 550-end.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : Pdgfra platelet derived growth factor receptor, alpha polypeptide [ Mus musculus ]
Synonyms : Pdgfra; platelet derived growth factor receptor, alpha polypeptide; CD140a; Pdgfr-2; AI115593; PDGF alpha chain; Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha); EC 2.7.10.1
Gene ID : 18595
mRNA Refseq : NM_001083316
Protein Refseq : NP_001076785
UniProt ID : P26618
Chromosome Location : 5 C3.3; 5 42.0 cM
Pathway : Calcium signaling pathway; Colorectal cancer; Cytokine-cytokine receptor interaction; Endocytosis; Focal adhesion; Gap junction; Glioma; Pathways in cancer; Regulation of actin cytoskeleton; MAPK signaling pathway
Function : ATP binding; nucleotide binding; platelet-derived growth factor alpha-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein heterodimerization activity; receptor activity; transferase activity; vascular endothelial growth factor receptor activity

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