"PDGFRB" Related Products

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Recombinant Human PDGFRB, GST-tagged, Active

Cat. No. : PDGFRB-386H
Product Overview : Recombinant Human full-length PDGFRB (557-end) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=104kDa.
Description : PDGFRβ (platelet-derived growth factor receptor) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. PDGFRβ deficient mice are hemorrhagic, severely anemic and exhibit a defect in kidney glomeruli function. However, absence of PDGFRβ has no impact on major blood vessels and the heart. PDGFRβexpression and activity is elevated in several cancers and inhibition of PDGFRβ activity blocks progression of renal carcinoma in an animal model.
Source : Sf9 insect cells using baculovirus.
Sequence : 557-end.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : PDGFRB platelet-derived growth factor receptor, beta polypeptide [ Homo sapiens ]
Synonyms : PDGFRB; platelet-derived growth factor receptor, beta polypeptide; JTK12; PDGFR; CD140B; PDGFR1; platelet-derived growth factor receptor beta; PDGF-R-beta; CD140 antigen-like family member B; EC 2.7.10.1; CD140b; PDGF-R-beta; CD140b antigen; soluble PDGFRb variant 1
Gene ID : 5159
mRNA Refseq : NM_002609
Protein Refseq : NP_002600
MIM : 173410
UniProt ID : P09619
Chromosome Location : 5q33.1
Pathway : Calcium signaling pathway; Colorectal cancer; Cytokine-cytokine receptor interaction; Focal adhesion; Gap junction; Glioma; MAPK signaling pathway; Melanoma; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton
Function : ATP binding; nucleotide binding; platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor receptor binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity

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