"PIM1" Related Products


Recombinant Human Pim-1 Oncogene, GST-tagged, Active

Cat. No.: PIM1-392H
Product Overview: Recombinant human full-length PIM1 was expressed by baculovirus inSf9 cells usingan N-terminal GST tag. MW=62 kDa.
Description: PIM1 is a proto-oncogene that belongs to a family of serine/threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from Moloney murine leukemia virus induced T-cell lymphomas in mice, PIM1 is involved in the control of cytokine-mediated cell proliferation, differentiation and survival of lymphoid and myeloid cells as well as others. Expression of PIM1 can be stimulated by a variety of growth factors and is regulated at four different levels: transcriptional, post-transcriptional, translational and post-translational. Expression of PIM1 is mediated through activation of the JAK/STAT pathway.
Source: Sf9 insect cells using baculovirus.
Sequence: Full-length.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: PIM1 pim-1 oncogene [ Homo sapiens ]
Synonyms: PIM1; pim-1 oncogene; PIM; Proto-oncogene serine/threonine-protein kinase Pim-1; EC
Gene ID: 5292
mRNA Refseq: NM_002648
Protein Refseq: NP_002639
UniProt ID: P11309
Chromosome Location: 6p21
MIM: 164960
Pathway: Acute myeloid leukemia; Jak-STAT signaling pathway
Function: ATP binding; nucleotide binding; transferase activity; manganese ion binding; protein serine/threonine kinase activity; metal ion binding; transcription factor binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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