Recombinant Human PKD2, GST-tagged, Active

• Cat.No.: PKD2-410H
• Product Overview: Recombinant full-length human PKD2 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=130kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: PKD2 is a novel phorbol ester- and growth factor-stimulated serine/threonine kinase that contains two cysteine-rich motifs at the N terminus, a pleckstrin homology domain, and a catalytic domain. It exhibits the strongest homology to the serine/threonine protein kinases PKD/PKCμ and PKCν. The PKD family of enzymes have been implicated in very diverse cellular functions, including Golgi organization and plasma membrane directed transport, metastasis, immune responses, apoptosis and cell proliferation.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: PKD2 polycystic kidney disease 2 (autosomal dominant) [ Homo sapiens ]
• Synonyms: PKD2; polycystic kidney disease 2 (autosomal dominant); PC2; PKD4; Pc-2; APKD2; TRPP2; MGC138466; MGC138468; polycystwin; polycystwin; transient receptor potential cation channel, subfamily P, member 2
• Gene ID: 5311
• mRNA Refseq: NM_000297
• Protein Refseq: NP_000288
• MIM: 173910
• UniProt ID: Q13563
• Chromosome Location: 4q21-q23
• Function: ATP binding; calcium ion binding; channel activity; cytoskeletal protein binding; ion channel activity; potassium channel activity; protein C-terminus binding; voltage-gated chloride channel activity; voltage-gated sodium channel activity