"ZAP70" Related Products

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Recombinant Human ZAP70, GST-tagged, Active

Cat. No. : ZAP70-458H
Product Overview : Recombinant full-length human ZAP70 was expressed bybaculovirusinSf9 insect cellsusing a N-terminal GST tag. MW = 96 kDa.
Description : ZAP70 is a non-receptor protein tyrosine kinase (part of the Syk/Zap70 family) that is involved in signaling by the T-cell antigen receptor (TCR). Ligation of the TCR/CD3 receptor in Jurkat T-cells induces phosphoprotein complexes which contain ZAP70. TCR zeta chains are initially phosphorylated by p56Lck that lead to the recruitment of ZAP70 via its SH2 domain. ZAP70 in turn phosphorylates other proteins in the TCR-phosphoprotein complex. One of the natural substrates for ZAP70 is the zeta-chain dimer of the TCR/CD3 complex.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : ZAP70 zeta-chain (TCR) associated protein kinase 70kDa [ Homo sapiens ]
Synonyms : ZAP70; zeta-chain (TCR) associated protein kinase 70kDa; SRK; STD; TZK; ZAP-70; FLJ17670; FLJ17679; zeta-chain (TCR) associated protein kinase (70 kD); Tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein Syk-related tyrosine kinase; EC 2.7.10.2; zeta-chain associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
Gene ID : 7535
mRNA Refseq : NM_001079
Protein Refseq : NP_001070
MIM : 176947
UniProt ID : P43403
Chromosome Location : 2q12
Pathway : Natural killer cell mediated cytotoxicity; Primary immunodeficiency; T cell receptor signaling pathway; Signaling in Immune system
Function : ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphotyrosine binding; transferase activity; protein binding

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