Recombinant Human PDE2A, GST-tagged, Active

• Cat.No.: PDE2A-472H
• Product Overview: Recombinant full-length human PDE2A was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=130kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: PDE2A is a member of the cyclic nucleotide phosphodiesterase family. PDE2A is a cGMP-specific phosphodiesterase and hydrolyzes cGMP to 5"-GMP. TNFα stimulation of cells leads to an increase in PDE2A expression in a p38 mitogen-activated protein kinase (MAPK)-dependent manner. TNFα-mediated up-regulation of PDE2A may destabilize endothelial barrier function in sepsis. In addition, selective PDE2A up-regulation sensitizesendothelial cells toward the permeability-increasing agent thrombin. Furthermore, PDE2A inhibition is effective in preventing thrombin-induced lung edema.
• Sequence: Full length.
• Applications: PDE Assay.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• 22q13.33: 11q13.4

Gene Information

• Gene Name: PDE2A phosphodiesterase 2A, cGMP-stimulated [ Homo sapiens ]
• Synonyms: PDE2A; phosphodiesterase 2A, calmodulin-dependent; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 4; phosphodiesterase 2A; PDE2A1; PED2A4; EC 3.1.4.17
• Gene ID: 5138
• mRNA Refseq: NM_001143839
• Protein Refseq: NP_001137311
• MIM: 602658
• UniProt ID: O00408
• Pathway: Progesterone-mediated oocyte maturation; Purine metabolism; Signaling by GPCR
• Function: cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; hydrolase activity; protein binding