Recombinant Human PDE2A, GST-tagged, Active PDE2A-472H

Cat. No. :	PDE2A-472H
Product Overview :	Recombinant full-length human PDE2A was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=130kDa.
Description :	PDE2A is a member of the cyclic nucleotide phosphodiesterase family. PDE2A is a cGMP-specific phosphodiesterase and hydrolyzes cGMP to 5"-GMP. TNFα stimulation of cells leads to an increase in PDE2A expression in a p38 mitogen-activated protein kinase (MAPK)-dependent manner. TNFα-mediated up-regulation of PDE2A may destabilize endothelial barrier function in sepsis. In addition, selective PDE2A up-regulation sensitizesendothelial cells toward the permeability-increasing agent thrombin. Furthermore, PDE2A inhibition is effective in preventing thrombin-induced lung edema.
Source :	Sf9 insect cells using baculovirus.
Sequence :	Full length.
Applications :	PDE Assay.
Storage And Stability :	Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
22q13.33 :	11q13.4

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Gene Name :	PDE2A phosphodiesterase 2A, cGMP-stimulated [ Homo sapiens ]
Synonyms :	PDE2A; phosphodiesterase 2A, calmodulin-dependent; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 4; phosphodiesterase 2A; PDE2A1; PED2A4; EC 3.1.4.17
Gene ID :	5138
mRNA Refseq :	NM_001143839
Protein Refseq :	NP_001137311
MIM :	602658
UniProt ID :	O00408
Pathway :	Progesterone-mediated oocyte maturation; Purine metabolism; Signaling by GPCR
Function :	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; hydrolase activity; protein binding