Recombinant Human PDE2A, GST-tagged, Active

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Recombinant Human PDE2A, GST-tagged, Active

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Cat. No. : PDE2A-472H
Product Overview : Recombinant full-length human PDE2A was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=130kDa.
Description : PDE2A is a member of the cyclic nucleotide phosphodiesterase family. PDE2A is a cGMP-specific phosphodiesterase and hydrolyzes cGMP to 5"-GMP. TNFα stimulation of cells leads to an increase in PDE2A expression in a p38 mitogen-activated protein kinase (MAPK)-dependent manner. TNFα-mediated up-regulation of PDE2A may destabilize endothelial barrier function in sepsis. In addition, selective PDE2A up-regulation sensitizesendothelial cells toward the permeability-increasing agent thrombin. Furthermore, PDE2A inhibition is effective in preventing thrombin-induced lung edema.
Source : Sf9 insect cells using baculovirus.
Sequence : Full length.
Applications : PDE Assay.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
22q13.33 : 11q13.4
PDB rendering based on 1mc0. :

Gene Name : PDE2A phosphodiesterase 2A, cGMP-stimulated [ Homo sapiens ]
Synonyms : PDE2A; phosphodiesterase 2A, calmodulin-dependent; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 4; phosphodiesterase 2A; PDE2A1; PED2A4; EC 3.1.4.17
Gene ID : 5138
mRNA Refseq : NM_001143839
Protein Refseq : NP_001137311
MIM : 602658
UniProt ID : O00408
Pathway : Progesterone-mediated oocyte maturation; Purine metabolism; Signaling by GPCR
Function : cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; hydrolase activity; protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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