- Human(7)
- Rhesus Macaque(1)
Recombinant Human PDE2A, GST-tagged, Active
Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.
Cat. No. : | PDE2A-472H |
Product Overview : | Recombinant full-length human PDE2A was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=130kDa. |
Description : | PDE2A is a member of the cyclic nucleotide phosphodiesterase family. PDE2A is a cGMP-specific phosphodiesterase and hydrolyzes cGMP to 5"-GMP. TNFα stimulation of cells leads to an increase in PDE2A expression in a p38 mitogen-activated protein kinase (MAPK)-dependent manner. TNFα-mediated up-regulation of PDE2A may destabilize endothelial barrier function in sepsis. In addition, selective PDE2A up-regulation sensitizesendothelial cells toward the permeability-increasing agent thrombin. Furthermore, PDE2A inhibition is effective in preventing thrombin-induced lung edema. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | Full length. |
Applications : | PDE Assay. |
Storage And Stability : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
22q13.33 : | 11q13.4 |
PDB rendering based on 1mc0. : |
![]() |
Gene Name : | PDE2A phosphodiesterase 2A, cGMP-stimulated [ Homo sapiens ] |
Synonyms : | PDE2A; phosphodiesterase 2A, calmodulin-dependent; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 4; phosphodiesterase 2A; PDE2A1; PED2A4; EC 3.1.4.17 |
Gene ID : | 5138 |
mRNA Refseq : | NM_001143839 |
Protein Refseq : | NP_001137311 |
MIM : | 602658 |
UniProt ID : | O00408 |
Pathway : | Progesterone-mediated oocyte maturation; Purine metabolism; Signaling by GPCR |
Function : | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; hydrolase activity; protein binding |
◆ Recombinant Protein
PDE2A-07H | Recombinant Human PDE2A Protein, His-tagged | +Inquiry |
PDE4B-146H | Recombinant Human PDE2A Protein, His-tagged | +Inquiry |
PDE2A -906H | Recombinant Human PDE2A , His tagged | +Inquiry |
PDE2A-606H | Recombinant Human PDE2A | +Inquiry |
PDE2A-29979TH | Recombinant Human PDE2A | +Inquiry |
|
◆ Lysates
PDE2A-591HCL | Recombinant Human PDE2A cell lysate | +Inquiry |
|
◆ Assay kits
Kit-1833 | PDE2A Assay Kit II | +Inquiry |
Kit-1832 | PDE2A Assay Kit I | +Inquiry |
|
Pde10a PDE11A PDE1A PDE1B Pde1c PDE2A PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDE5A PDE6B PDE6C PDE6D PDE7A PDE7B PDE8A PDE9A PDE4DIP PDE12 PDE6A PDE8B PDE6G PDE6H
Easy access to products and services you need from our library via powerful searching tools.
Copyright © 2022 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy