|Cat. No. :
|Product Overview :
||Recombinant full-length human PDE2A was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=130kDa.
||PDE2A is a member of the cyclic nucleotide phosphodiesterase family. PDE2A is a cGMP-specific phosphodiesterase and hydrolyzes cGMP to 5"-GMP. TNFα stimulation of cells leads to an increase in PDE2A expression in a p38 mitogen-activated protein kinase (MAPK)-dependent manner. TNFα-mediated up-regulation of PDE2A may destabilize endothelial barrier function in sepsis. In addition, selective PDE2A up-regulation sensitizesendothelial cells toward the permeability-increasing agent thrombin. Furthermore, PDE2A inhibition is effective in preventing thrombin-induced lung edema.
||Sf9 insect cells using baculovirus.
|Storage And Stability :
||Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.