Recombinant Human PDE3B, GST-tagged, Active
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Cat. No. : | PDE3B-474H |
Product Overview : | Recombinanthuman PDE3B (654-end) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=85kDa. |
Description : | PDE3B is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP and cGMP. PDE3B has high affinity for cAMP and is inhibited by cGMP as well as specific inhibitors such as cilostamide and milrinone. PDE3B is phosphorylated and activated in response to insulin and agents that increase cAMP. Leptin can increase the activity of PDE3B in the hypothalamus leading to a decrease in cAMP concentration. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | 654-end. |
Applications : | PDE Assay. |
Storage And Stability : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
22q13.33 : | 11p15 |
Gene Name : | PDE3B phosphodiesterase 3B, cGMP-inhibited [ Homo sapiens ] |
Synonyms : | PDE3B; phosphodiesterase 3B, calmodulin-dependent; HcGIP1; cGIPDE1; cyclic nucleotide phosphodiesterase; phosphodiesterase 3B; EC 3.1.4.17 |
Gene ID : | 5140 |
mRNA Refseq : | NM_000922 |
Protein Refseq : | NP_000913 |
MIM : | 602047 |
UniProt ID : | Q13370 |
Pathway : | Progesterone-mediated oocyte maturation; Purine metabolism; Signaling by GPCR; Insulin signaling pathway |
Function : | 3",5"-cyclic-AMP phosphodiesterase activity; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; hydrolase activity; hydrolase activity; protein kinase B binding |
◆ Recombinant Protein
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PDE3B-2849C | Recombinant Chicken PDE3B | +Inquiry |
PDE3B-4329R | Recombinant Rat PDE3B Protein | +Inquiry |
PDE3B-3492H | Recombinant Human PDE3B protein, His-tagged | +Inquiry |
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◆ Assay kits
Kit-1836 | PDE3B Assay Kit I | +Inquiry |
Kit-1837 | PDE3B Assay Kit II | +Inquiry |
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Pde10a PDE11A PDE1A PDE1B Pde1c PDE2A PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDE5A PDE6B PDE6C PDE6D PDE7A PDE7B PDE8A PDE9A PDE4DIP PDE12 PDE6A PDE8B PDE6G PDE6H
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