Cat. No.:	PDE3B-474H
Product Overview:	Recombinanthuman PDE3B (654-end) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=85kDa.
Description:	PDE3B is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP and cGMP. PDE3B has high affinity for cAMP and is inhibited by cGMP as well as specific inhibitors such as cilostamide and milrinone. PDE3B is phosphorylated and activated in response to insulin and agents that increase cAMP. Leptin can increase the activity of PDE3B in the hypothalamus leading to a decrease in cAMP concentration.
Source:	Sf9 insect cells using baculovirus.
Sequence:	654-end.
Applications:	PDE Assay.
Storage And Stability:	Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
22q13.33:	11p15

Gene Name:	PDE3B phosphodiesterase 3B, cGMP-inhibited [ Homo sapiens ]
Synonyms:	PDE3B; phosphodiesterase 3B, calmodulin-dependent; HcGIP1; cGIPDE1; cyclic nucleotide phosphodiesterase; phosphodiesterase 3B; EC 3.1.4.17
Gene ID:	5140
mRNA Refseq:	NM_000922
Protein Refseq:	NP_000913
MIM:	602047
UniProt ID:	Q13370
Pathway:	Progesterone-mediated oocyte maturation; Purine metabolism; Signaling by GPCR; Insulin signaling pathway
Function:	3",5"-cyclic-AMP phosphodiesterase activity; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; hydrolase activity; hydrolase activity; protein kinase B binding

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