"PDE7A" Related Products


Recombinant Human Phosphodiesterase 7A, GST-tagged, Active

Cat. No. : PDE7A-481H
Product Overview : Recombinant human PDE7A (104-end) was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 64 kDa.
Description : PDE7A is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP and cGMP. PDE7A is a high-affinity cAMP-specific PDE and is expressed in T cell lines, peripheral blood T lymphocytes, epithelial cell lines, airway and vascular smooth muscle cells, lung fibroblasts, and eosinophils. PDE7 plays a critical role in the regulation of human T cell function and selective PDE7 inhibitors are being examined to treat immunological and inflammatory disorders. PDE7A plays an important role in the regulation of osteoblastic differentiation. PDE7A depletion by RNAi upregulates expression of several osteogenic genes and increases mineralization.
Source : Sf9 insect cells using baculovirus.
Sequence : 104-end.
Applications : PDE Assay.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : PDE7A phosphodiesterase 7A [ Homo sapiens ]
Synonyms : PDE7A; phosphodiesterase 7A; HCP1; PDE7; phosphodiesterase isozyme 7; EC; High affinity cAMP-specific 3",5"-cyclic phosphodiesterase 7A; TM22
Gene ID : 5150
mRNA Refseq : NM_002603
Protein Refseq : NP_002594
MIM : 171885
UniProt ID : Q13946
Chromosome Location : 8q13
Pathway : Progesterone-mediated oocyte maturation; Purine metabolism
Function : 3",5"-cyclic-AMP phosphodiesterase activity; hydrolase activity

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