Recombinant Human Transforming Growth Factor, Beta 2, Monomeric Form

• Cat.No.: TGFB2-467H
• Product Overview: Recombinant human TGFβ-2 is a 25.4 kDa protein composed of two identical 112 amino acid peptide chains linked by a single disulfide bond. It was expressed inNicotiana benthamiana.Recombinant human TGFβ-2 is purified by sequential chromatography (FPLC). This product contains no animal –derived components or impurities.

Specification

• Cat. No.: TGFB2-467H
• Description: Transforming growth factor –β is a family of five related cytokines that have been shown on a wide variety of normal and neoplastic cells, indicating the importance of these homodimeric proteins as multi-functional regulators of cellular activity. The three mammalian isoforms of TGFβ (TGFβ-1, TGFβ-2 and TGFβ-3 ) signal through the same receptor and elicit similar biological responses. They are involved in physiological processes as embryogenesis, tissue remodelling and wound healing.
• Source: Nicotiana benthamiana.
• Molecular Formula: C 602H909N167O171S10.
• Extinction Coefficient: E 0.1% 2.02 (A 280 nm).
• P.I: 7.72.
• Purity Assay: >98 % as determinate by SDS-PAGE gel.
• Endotoxin Level: < 0.04 EU/ µg protein (LAL method).
• Molecular Weight: recombinant protein 13.54 kDa, monomer form of 118 amino acid polypeptide chain.
• Formulation: Lyophilized from a buffer of Tris HCl 0.05M pH 7.4.
• Stotage And Stability: This lyophilized preparation is stable at 2-8° C, but should be kept at –20°C for long term storage. Repeated freezing and thawing is not recommended.

Gene Information

• Gene Name: TGFB2 transforming growth factor, beta 2 [ Homo sapiens ]
• Synonyms: TGFB2; Transforming growth factor beta 2; MGC116892; TGF-beta2; Transforming growth factor beta-2; TGF-beta-2; Glioblastoma-derived T-cell suppressor factor; G-TSF; BSC-1 cell growth inhibitor; Polyergin; Cetermin
• Gene ID: 7042
• mRNA Refseq: NM_001135599
• Protein Refseq: NP_001129071
• MIM: 190220
• UniProt ID: P61812
• Chromosome Location: 1q41
• Pathway: Cell cycle; Chronic myeloid leukemia; Cytokine-cytokine receptor interaction; Dilated cardiomyopathy; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway; Pathways in cancer; Renal cell carcinoma; TGF-beta signaling pathway; Hemostasis
• Function: beta-amyloid binding; cytokine activity; protein heterodimerization activity; growth factor activity; type II transforming growth factor beta receptor binding; receptor signaling protein serine/threonine kinase activity