Recombinant Human Ras Homolog Enriched In Brain, His-tagged

• Cat.No.: RHEB-384H
• Product Overview: Recombinant full-length human RHEB was expressed usingbaculovirusinSf9 cellsusing a N-terminal His tag. MW = 21kDa.

Specification

• Cat. No.: RHEB-384H
• Description: RHEB is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. RHEB is vital in the regulation of growth and cell cycle progression. RHEB has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form. Drosophila RHEB is a direct target of Tsc2 GTPase-activating protein (GAP) activity both in vivo and in vitro. Point mutations in the Drosophila RHEB gene inhibits cell growth while overexpression promotes cell growth. RHEB functions downstream of Tsc1 and Tsc2 in the mTOR signaling pathway.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: RHEB Ras homolog enriched in brain [ Homo sapiens ]
• Synonyms: Ras homolog enriched in brain; RHEB2; MGC111559; RHEB; GTP-binding protein Rheb; Ras homolog enriched in brain 2; Ras homolog enriched in brain
• Gene ID: 6009
• mRNA Refseq: NM_005614
• Protein Refseq: NP_005605
• MIM: 601293
• UniProt ID: Q15382
• Chromosome Location: 7q36
• Pathway: Insulin signaling pathway; mTOR signaling pathway; Signaling by Insulin receptor
• Function: GTP binding; GTPase activity; nucleotide binding