"TGFB3" Related Products

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Recombinant Human Transforming Growth Factor, Beta 3, Dimeric Form

Cat. No.: TGFB3-468H
Product Overview: Recombinant human TGFβ-3 is a 25.4 kDa protein composed of two identical 112 amino acid peptide chains linked by a single disulfide bond. It was expressed inNicotiana benthamiana.Recombinant human TGFβ-3 is purified by sequential chomatograpy (FPLC). This product contains no animal –derived components or impurities.
Description: Transforming growth factor –β is a family of five related cytokines that have been shown on a wide variety of normal and neoplastic cells, indicating the importance of these homodimeric proteins as multi-functional regulators of cellular activity. The three mammalian isoforms of TGFβ (TGFβ-1, TGFβ-2 and TGFβ-3 ) signal through the same receptor and elicit similar biological responses. They are involved in physiological processes as embryogenesis, tissue remodelling and wound healing.
Source: Nicotiana benthamiana.
Molecular Formula: C 600H902N166O174S10.
Extinction Coefficient: E0.1% = 1.729 (A280 nm).
P.I: 6.75.
Purity Assay: >95 % as determinate by SDS-PAGE gel.
Endotoxin Level: < 0.04 EU/ µg protein (LAL method).
Formulation: Lyophilized from a buffer of Tris HCl 0.05M pH 7.4.
Activity: The biological activity of TGF-β3 is measured in culture by its ability to inhibit the mink lung epithelial cells proliferation. (ED50 is defined as the effective concentration of growth factor that elicits a 50% inhibition in cell growth in a cell based bioassay).
Stotage And Stability: This lyophilized preparation is stable at 2-8° C, but should be kept at –20°C for long term storage. Repeated freezing and thawing is not recommended.
Gene Name: TGFB3 transforming growth factor, beta 3 [ Homo sapiens ]
Synonyms: Transforming Growth Factor-beta3; TGFB3; ARVD; FLJ16571; TGF-beta3; transforming growth factor, beta 3
Gene ID: 7043
mRNA Refseq: NM_003239
Protein Refseq: NP_003230
MIM: 190230
UniProt ID: P10600
Chromosome Location: 4q24
Pathway: Cell cycle;Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway; Pancreatic cancer;Pathways in cancer; Renal cell carcinoma; TGF-beta signaling pathway
Function: Growth factor activity; Identical protein binding; Protein heterodimerization activity; Transforming growth factor beta binding; Type I transforming growth factor beta receptor binding; Type II transforming growth factor beta receptor binding

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