Recombinant Human ALDOB

• Cat.No.: ALDOB-26495TH
• Product Overview: Recombinant fragment of Human ALDOB with an N terminal proprietary tag; Predicted MWt 34.76 kDa.

Specification

• Description: Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related housekeeping genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.
• Protein length: 83 amino acids
• Molecular Weight: 34.760kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: DSQGKLFRNILKEKGIVVGIKLDQG GAPLAGTNKETTIQGLDGLSERCAQ YKKDGVDFGKWRAVLRIADQCPSSL AIQENANA
• Sequence Similarities: Belongs to the class I fructose-bisphosphate aldolase family.

Gene Information

• Gene Name: ALDOB aldolase B, fructose-bisphosphate [ Homo sapiens ]
• Official Symbol: ALDOB
• Synonyms: ALDOB; aldolase B, fructose-bisphosphate; fructose-bisphosphate aldolase B
• Gene ID: 229
• mRNA Refseq: NM_000035
• Protein Refseq: NP_000026
• MIM: 612724
• Uniprot ID: P05062
• Chromosome Location: 9q21.3-q22.2
• Pathway: FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Fructose and mannose metabolism, organism-specific biosystem; Fructose and mannose metabolism, conserved biosystem; Fructose catabolism, organism-specific biosystem; Gluconeogenesis, organism-specific biosystem
• Function: ATPase binding; cytoskeletal protein binding; fructose binding; fructose-bisphosphate aldolase activity; fructose-bisphosphate aldolase activity