Recombinant Human ALOX15B

• Cat.No.: ALOX15B-26021TH
• Product Overview: Recombinant fragment of Human 15 Lipoxygenase 2 with N terminal proprietary tag, 36.63kDa inclusive of tag.

Specification

• Description: This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.
• Protein length: 100 amino acids
• Molecular Weight: 36.630kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Expressed in hair, prostate, lung and cornea.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: NANFYLQAGSAFAEMKIKGLLDRKG LWRSLNEMKRIFNFRRTPAAEHAFE HWQEDAFFASQFLNGLNPVLIRRCH YLPKNFPVTDAMVASVLGPGTSLQA
• Sequence Similarities: Belongs to the lipoxygenase family.Contains 1 lipoxygenase domain.Contains 1 PLAT domain.

Gene Information

• Gene Name: ALOX15B arachidonate 15-lipoxygenase, type B [ Homo sapiens ]
• Official Symbol: ALOX15B
• Synonyms: ALOX15B; arachidonate 15-lipoxygenase, type B; arachidonate 15 lipoxygenase, second type; arachidonate 15-lipoxygenase B; 15 LOX 2
• Gene ID: 247
• mRNA Refseq: NM_001039130
• Protein Refseq: NP_001034219
• MIM: 603697
• Uniprot ID: O15296
• Chromosome Location: 17p13.1
• Pathway: Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Eicosanoid Synthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Selenium Pathway, organism-specific biosystem
• Function: arachidonate 15-lipoxygenase activity; iron ion binding; lipoxygenase activity; metal ion binding; oxidoreductase activity