Cat.No.: |
ANGPTL3-26574TH |
Product Overview: |
Recombinant full length Human ANGPTL3 fused at the C terminus to a DDDDK tag; mwt: 60 kDa by SDS PAGE. |
Description: |
The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. |
Protein length: |
460 amino acids |
Conjugation: |
FLAG |
Molecular Weight: |
60.000kDa inclusive of tags |
Source: |
HEK 293 cells |
Tissue specificity: |
Expressed principally in liver. Weakly expressed in kidney. |
Biological activity: |
Activates ERK phosphorylation in THP-1 cells. |
Form: |
Liquid |
Purity: |
>90% by SDS-PAGE |
Storage buffer: |
Preservative: NoneConstituents: PBS |
Storage: |
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities: |
Contains 1 fibrinogen C-terminal domain. |