Recombinant Human ANGPTL3, FLAG-tagged


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Recombinant Human ANGPTL3, FLAG-tagged

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Cat.No. : ANGPTL3-26574TH
Product Overview : Recombinant full length Human ANGPTL3 fused at the C terminus to a DDDDK tag; mwt: 60 kDa by SDS PAGE.
Description : The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.
Protein length : 460 amino acids
Conjugation : FLAG
Molecular Weight : 60.000kDa inclusive of tags
Source : HEK 293 cells
Tissue specificity : Expressed principally in liver. Weakly expressed in kidney.
Biological activity : Activates ERK phosphorylation in THP-1 cells.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: PBS
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Contains 1 fibrinogen C-terminal domain.
Gene Name : ANGPTL3 angiopoietin-like 3 [ Homo sapiens ]
Official Symbol : ANGPTL3
Synonyms : ANGPTL3; angiopoietin-like 3; ANGPT5; angiopoietin-related protein 3; angiopoietin 5;
Gene ID : 27329
mRNA Refseq : NM_014495
Protein Refseq : NP_055310
MIM : 604774
Uniprot ID : Q9Y5C1
Chromosome Location : 1p31.1-p22.3
Pathway : Integrins in angiogenesis, organism-specific biosystem;
Function : cell surface binding; enzyme inhibitor activity; growth factor activity; integrin binding; phospholipase inhibitor activity;

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