Cat.No.:	ANGPTL3-26574TH
Product Overview:	Recombinant full length Human ANGPTL3 fused at the C terminus to a DDDDK tag; mwt: 60 kDa by SDS PAGE.
Description:	The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.
Protein length:	460 amino acids
Conjugation:	FLAG
Molecular Weight:	60.000kDa inclusive of tags
Source:	HEK 293 cells
Tissue specificity:	Expressed principally in liver. Weakly expressed in kidney.
Biological activity:	Activates ERK phosphorylation in THP-1 cells.
Form:	Liquid
Purity:	>90% by SDS-PAGE
Storage buffer:	Preservative: NoneConstituents: PBS
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities:	Contains 1 fibrinogen C-terminal domain.

Gene Name:	ANGPTL3 angiopoietin-like 3 [ Homo sapiens ]
Official Symbol:	ANGPTL3
Synonyms:	ANGPTL3; angiopoietin-like 3; ANGPT5; angiopoietin-related protein 3; angiopoietin 5;
Gene ID:	27329
mRNA Refseq:	NM_014495
Protein Refseq:	NP_055310
MIM:	604774
Uniprot ID:	Q9Y5C1
Chromosome Location:	1p31.1-p22.3
Pathway:	Integrins in angiogenesis, organism-specific biosystem;
Function:	cell surface binding; enzyme inhibitor activity; growth factor activity; integrin binding; phospholipase inhibitor activity;

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