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Recombinant Human ARL4D, His-tagged

Cat.No. : ARL4D-27056TH
Product Overview : Recombinant full length Human ARF4L with N terminal His tag; 221 amino acids with tag, Predicted MWt 24.3 kDa.
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Description : ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS).
Protein length : 201 amino acids
Conjugation : HIS
Molecular Weight : 24.300kDa inclusive of tags
Source : E. coli
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : pH: 8.00Constituents:0.32% Tris HCl, 0.03% DTT, 20% Glycerol, 1.17% Sodium chloride
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHHSSGLVPRGSHMGNHLTEMAPTASSFLPHFQ ALHVVVIGLDSAGKTSLLYRLKFKEFVQSVPTKGFNTE KIRVPLGGSRGITFQVWDVGGQEKLRPLWRSYTRRTDGLV FVVDAAEAERLEEAKVELHRISRASDNQGVPVLVLANK QDQPGALSAAEVEKRLAVRELAAATLTHVQGCSAVDGLGL QQGLERLYEMILKRKKAARGGKKRR
Sequence Similarities : Belongs to the small GTPase superfamily. Arf family.
Gene Name : ARL4D ADP-ribosylation factor-like 4D [ Homo sapiens ]
Official Symbol : ARL4D
Synonyms : ARL4D; ADP-ribosylation factor-like 4D; ADP ribosylation factor 4 like , ARF4L; ADP-ribosylation factor-like protein 4D;
Gene ID : 379
mRNA Refseq : NM_001661
Protein Refseq : NP_001652
MIM : 600732
Uniprot ID : P49703
Chromosome Location : 17q12-q21
Function : GTP binding; GTPase activity; nucleotide binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (16)

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Can genetic mutations in ARL4D lead to disease? 02/05/2023

Although rare, some genetic mutations in ARL4D have been identified in certain diseases. For example, mutations in ARL4D have been associated with retinitis pigmentosa, a genetic disorder affecting the retina. However, further studies are needed to fully understand the extent and implications of these mutations.

Can changes in ARL4D expression levels impact cell behavior? 12/12/2021

Yes, alterations in ARL4D expression can impact various cellular behaviors. Increased expression of ARL4D has been associated with enhanced cell migration, invasion, and metastasis in cancer cells. Additionally, aberrant ARL4D expression may disrupt normal cellular processes, leading to disease phenotypes.

Does ARL4D have any known roles in diseases? 12/04/2021

ARL4D has been associated with various diseases and pathological conditions. Its dysregulation has been observed in several types of cancer, where increased expression of ARL4D has been linked to enhanced metastatic potential and poor patient prognosis. ARL4D has also been implicated in neurodegenerative diseases, where it may contribute to abnormal vesicular trafficking and protein aggregation in neurons.

Are there any known post-translational modifications of ARL4D? 07/29/2021

Yes, ARL4D can undergo post-translational modifications, including prenylation and palmitoylation. These lipid modifications help anchor ARL4D to cellular membranes, thus influencing its subcellular localization and activity.

Are there any disease-specific mutations identified in the ARL4D gene? 07/18/2021

While there are currently no reports of disease-specific mutations in the ARL4D gene, dysregulation of ARL4D expression levels has been observed in certain diseases, particularly cancer. Investigations into potential ARL4D mutations and their impact on disease development are ongoing.

Is there any evidence of ARL4D involvement in signal transduction pathways? 12/15/2020

Yes, ARL4D has been implicated in signal transduction pathways. It has been shown to modulate the activity of Rho family GTPases, such as Rac1 and Cdc42, which are key regulators of cytoskeletal dynamics and cellular signaling. ARL4D can also interact with and regulate other signaling proteins involved in vesicular trafficking and cellular processes.

Does ARL4D have any disease associations? 11/10/2020

ARL4D has been implicated in several diseases and disorders. For example, it has been linked to the progression of cancer, where abnormal expression of ARL4D can contribute to tumor growth, metastasis, and drug resistance. Its dysregulation has also been associated with neurological disorders and retinal diseases.

Can ARL4D be targeted for therapeutic purposes? 08/09/2020

While there are currently no specific drugs targeting ARL4D, its involvement in various diseases makes it a potential therapeutic target. Understanding the underlying mechanisms of ARL4D function and identifying small molecules or inhibitors that can modulate its activity may hold promise for developing therapeutic interventions in the future.

In what cellular processes is ARL4D involved? 02/20/2020

ARL4D is involved in several cellular processes. It plays a role in vesicular trafficking, including the regulation of endosome organization, protein sorting, and membrane trafficking. ARL4D also contributes to cytoskeletal organization by promoting actin filament assembly and stabilization. Moreover, it has been implicated in cell migration, invasion, and metastasis in cancer cells.

What are the functional consequences of ARL4D knockdown or knockout? 05/31/2019

Studies involving ARL4D knockdown or knockout have shown various functional consequences. Knockdown or depletion of ARL4D has been reported to inhibit cell migration and invasion, reduce actin polymerization, and impair endocytic trafficking. Furthermore, ARL4D knockout in animal models has revealed defects in embryonic development and impaired neuronal migration.

Is ARL4D targeted for therapeutic interventions? 05/02/2019

The potential therapeutic targeting of ARL4D is an area of ongoing research. Given its involvement in cancer progression and other diseases, there is interest in exploring the development of drugs or strategies to modulate its activity for therapeutic purposes.

Are there any known interacting proteins or binding partners of ARL4D? 01/20/2019

Yes, several proteins have been identified as interacting partners of ARL4D. Some examples include the ARF-like protein 4 (ARL4A), ARF-like protein 4B (ARL4B), ARL4C, and ARL4-like protein (ARL4L), which belong to the same family of small GTPases. Other interacting proteins include certain Rab GTPases, Rho family GTPases (such as Rac1 and Cdc42), and various effector proteins involved in vesicular trafficking and cytoskeletal dynamics.

Is ARL4D conserved across different species? 11/25/2018

Yes, ARL4D is evolutionarily conserved among different species. Homologs of ARL4D can be found in organisms ranging from yeast to humans, suggesting its importance in fundamental cellular processes. The amino acid sequences and functional domains of ARL4D show significant conservation across species.

Are there any known inhibitors or activators of ARL4D? 12/03/2017

Currently, there are limited specific inhibitors or activators targeting ARL4D. However, studies focused on understanding the regulatory mechanisms and identifying small molecules that modulate ARL4D's activity may pave the way for developing drugs that can target this protein.

How does ARL4D contribute to cytoskeletal organization? 10/14/2016

ARL4D influences cytoskeletal organization by interacting with and regulating the activity of actin-binding proteins. It promotes actin filament assembly and stabilization, leading to the formation of actin-rich structures such as lamellipodia and filopodia necessary for cell migration and shape changes.

Are there any known interacting partners of ARL4D? 02/27/2016

ARL4D interacts with various binding partners to perform its functions. Some of its known interacting proteins include effector proteins involved in vesicle trafficking (such as ARF-binding proteins), regulators of actin cytoskeleton dynamics, and signaling molecules like kinases and GTPase-activating proteins.

Customer Reviews (8)

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Reviews
01/24/2023

    This unique capability to selectively bind to exposed PS simplifies the identification and quantification of different cellular populations, reducing experimental errors and enhancing accuracy.

    12/30/2022

      By choosing the ARL4D protein and partnering with the manufacturer, researchers can confidently conduct their trials, achieve reliable results, and contribute to groundbreaking discoveries.

      06/05/2022

        Collaborating with the manufacturer opens up possibilities for potential collaboration and exchange of information with a wider scientific community, allowing researchers to stay at the forefront of advancements in their respective fields.

        12/10/2019

          This includes complementary reagents, protocols, and access to an extensive knowledge base, all aimed at streamlining the trial process and maximizing the chances of achieving meaningful results.

          09/22/2017

            the ARL4D protein offers numerous advantages for researchers conducting trials due to its high quality and stability.

            10/01/2016

              This may include providing detailed protocols, troubleshooting guidance, and access to knowledgeable experts who can answer any inquiries or concerns.

              08/23/2016

                Its stability and purity make it an ideal candidate for studying protein structures at a high resolution, providing crucial insights into the organization and function of the ARL4D protein.

                08/01/2016

                  They can provide technical assistance, ensuring optimal utilization of the product.

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