Recombinant Human BCL2-Associated Athanogene, GST-tagged

• Cat.No.: BAG1-1434H
• Product Overview: Recombinant human BAG1 (72-end) was expressed inE. colicells using an N-terminal GST tag. MW = 66kDa.

Specification

• Cat. No.: BAG1-1434H
• Description: BAG1 (also known as BCL2-associated athanogene) is a membrane protein rich in glutamic acid residues that binds to BCL2 and blocks apoptosis or programmed cell death. The BAG1-BCL2 complex enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Overexpression of BAG1 in 3T3 fibroblasts prevents apoptosis in the presence of low serum. BAG1 has also been shown to interact with activated glucocorticoid, androgen, estrogen and progesterone receptors. Binding to these receptors by BAG1 is dependent on receptor activation.
• Source: E. coli.
• Sequence: 72-end.
• Applications: Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: BAG1 BCL2-associated athanogene [ Homo sapiens ]
• Synonyms: BAG1; BCL2-associated athanogene; RAP46; BAG-1; HAP; BCL2-associated athanogene 1; Bcl-2-associated athanogene 1; Glucocorticoid receptor-associated protein RAP46
• Gene ID: 573
• mRNA Refseq: NM_004323
• Protein Refseq: NP_004314
• MIM: 601497
• UniProt ID: Q99933
• Chromosome Location: 9p12
• Function: protein binding; receptor signaling protein activity