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Recombinant Human ATG4B, His-tagged

Cat.No. : ATG4B-26192TH
Product Overview : Recombinant full length protein, corresponding to amino acids 1-393 of Human ATG4B with N terminal His tag, 58kDa.
  • Specification
  • Gene Information
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Description : Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Conjugation : HIS
Source : E. coli
Tissue specificity : Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.
Form : Lyophilised:Reconstitute with 65 μl aqua dest.
Storage buffer : Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : MDAATLTYDTLRFAEFEDFPETSEP VWILGRKYSIFTEKD EILSDVASRLWFTYRKNFPAIGGTG PTSDTGWGCMLRC GQMIFAQALVCRHLGRDWRWTQRKR QPDSYFSVLNAFIDRKDSYYSIHQI AQMGVGEGKSIGQWYGPNTVAQVLK KLA VFDTWSSLAVHIAMDNTVVMEEIRR LCRTSVPCAGATA FPADSDRHCNGFPAGAEVTNRPSPW RPLVLLIPLRLGLTDINEAYVETLK HCFMMPQSLGVIGGKPNSAHYFIGY VGE ELIYLDPHTTQPAVEPTDGCFIPDE SFHCQHPPCRMSI AELDPSIAVGFFCKTEDDFNDWCQQ VKKLSLLGGALPMFELVELQPSHLA CPDVLNLSLDSSDVERLERFFDSED EDF EILSL
Sequence Similarities : Belongs to the peptidase C54 family.
Gene Name : ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae) [ Homo sapiens ]
Official Symbol : ATG4B
Synonyms : ATG4B; ATG4 autophagy related 4 homolog B (S. cerevisiae); APG4 autophagy 4 homolog B (S. cerevisiae) , APG4B; cysteine protease ATG4B; Apg4B; AUTL1; DKFZp586D1822; KIAA0943;
Gene ID : 23192
mRNA Refseq : NM_013325
Protein Refseq : NP_037457
MIM : 611338
Uniprot ID : Q9Y4P1
Chromosome Location : 2q37.3
Pathway : Regulation of autophagy, organism-specific biosystem; Regulation of autophagy, conserved biosystem;
Function : cysteine-type peptidase activity; peptidase activity; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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