Recombinant Human CTNNA1,GST-tagged

• Cat.No.: CTNNA1-1440H
• Product Overview: Recombinant full-length human Catenin alpha was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW = 123kDa.

Specification

• Cat. No.: CTNNA1-1440H
• Description: Catenin α is a novel actin-binding and -bundling protein. Catenin α is responsible for organizing and tethering actin filaments at the zones of E-cadherin-mediated cell-cell contact. Monomeric Catenin α can bind strongly to E-Cadherin-β-Catenin, whereas the dimer preferentially binds actin filaments. Different molecular conformations are associated with these different binding states, indicating that Catenin α is an allosteric protein. Catenin α directly regulates actin-filament organization by suppressing Arp2/3-mediated actin polymerization, likely by competing with the Arp2/3 complex for binding to actin filaments.
• Source: Sf9 insect cells using baculovirus.
• Sequence: Full-length.
• Applications: Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa [ Homo sapiens ]
• Synonyms: CTNNA1; catenin (cadherin-associated protein), alpha 1, 102kDa; CAP102; FLJ36832; FLJ52416; Catenin alpha-1; Cadherin-associated protein; Alpha E-catenin; NY-REN-13 antigen
• Gene ID: 1495
• mRNA Refseq: NM_001903
• Protein Refseq: NP_001894
• MIM: 116805
• UniProt ID: P35221
• Chromosome Location: 5q31.2
• Pathway: Adherens junction; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Endometrial cancer; Leukocyte transendothelial migration; Pathways in cancer; Tight junction; Cell-cell adhesion systems
• Function: cadherin binding; protein binding; structural molecule activity; vinculin binding