"CTNNA1" Related Products


Recombinant Human CTNNA1,GST-tagged

Cat. No. : CTNNA1-1440H
Product Overview : Recombinant full-length human Catenin alpha was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW = 123kDa.
Description : Catenin α is a novel actin-binding and -bundling protein. Catenin α is responsible for organizing and tethering actin filaments at the zones of E-cadherin-mediated cell-cell contact. Monomeric Catenin α can bind strongly to E-Cadherin-β-Catenin, whereas the dimer preferentially binds actin filaments. Different molecular conformations are associated with these different binding states, indicating that Catenin α is an allosteric protein. Catenin α directly regulates actin-filament organization by suppressing Arp2/3-mediated actin polymerization, likely by competing with the Arp2/3 complex for binding to actin filaments.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa [ Homo sapiens ]
Synonyms : CTNNA1; catenin (cadherin-associated protein), alpha 1, 102kDa; CAP102; FLJ36832; FLJ52416; Catenin alpha-1; Cadherin-associated protein; Alpha E-catenin; NY-REN-13 antigen
Gene ID : 1495
mRNA Refseq : NM_001903
Protein Refseq : NP_001894
MIM : 116805
UniProt ID : P35221
Chromosome Location : 5q31.2
Pathway : Adherens junction; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Endometrial cancer; Leukocyte transendothelial migration; Pathways in cancer; Tight junction; Cell-cell adhesion systems
Function : cadherin binding; protein binding; structural molecule activity; vinculin binding

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