"BAK1" Related Products


Recombinant Human BAK1

Cat.No.: BAK1-26168TH
Product Overview: Recombinant fragment corresponding to amino acids 100-211 of Human Bak with an N terminal proprietary tag; Predicted MWt 37.95 kDa.
Description: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Protein length: 112 amino acids
Molecular Weight: 37.950kDa inclusive of tags
Source: Wheat germ
Tissue specificity: Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
Form: Liquid
Purity: Proprietary Purification
Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the Bcl-2 family.
Gene Name: BAK1 BCL2-antagonist/killer 1 [ Homo sapiens ]
Official Symbol: BAK1
Synonyms: BAK1; BCL2-antagonist/killer 1; CDN1; bcl-2 homologous antagonist/killer; BAK; BCL2L7;
Gene ID: 578
mRNA Refseq: NM_001188
Protein Refseq: NP_001179
MIM: 600516
Uniprot ID: Q16611
Chromosome Location: 6p21.31
Pathway: Activation and oligomerization of BAK protein, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; Intrinsic Pathway for Apoptosis, organism-specific biosystem;
Function: BH domain binding; chaperone binding; heat shock protein binding; identical protein binding; metal ion binding;

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