Recombinant Human BARD1


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Recombinant Human BARD1

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Cat.No. : BARD1-26645TH
Product Overview : Recombinant fragment, corresponding to amino acids 658-757 of Human BARD1, with an N-terminal proprietary tag, predicted MWt 36.63 kDa
Description : This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa inclusive of tags
Source : Wheat germ
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Contains 4 ANK repeats.Contains 2 BRCT domains.Contains 1 RING-type zinc finger.
Gene Name : BARD1 BRCA1 associated RING domain 1 [ Homo sapiens ]
Official Symbol : BARD1
Synonyms : BARD1; BRCA1 associated RING domain 1; BRCA1-associated RING domain protein 1;
Gene ID : 580
mRNA Refseq : NM_000465
Protein Refseq : NP_000456
MIM : 601593
Uniprot ID : Q99728
Chromosome Location : 2q34-q35
Pathway : BARD1 signaling events, organism-specific biosystem;
Function : RNA binding; kinase binding; ligase activity; metal ion binding; protein binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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