"IRS1" Related Products


Recombinant Human Insulin Receptor Substrate 1, GST-tagged

Cat. No. : IRS1-1466H
Product Overview : Recombinant human IRS1 (600-1245) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 118kDa.
Description : IRS1 is the substrate for the insulin tyrosine kinase receptor and is found in a variety of insulin-responsive cells and tissues. IRS1 protein has no intrinsic enzymatic activity but acts as a docking protein, via the SH2 domains, for mediating the insulin downstream signaling events. IRS1 has been shown to associate with the 14-3-3 family of proteins and this could play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS1. IRS1 may be associated with colorectal cancer and diet and related factors may affect the risk by modifying plasma insulin levels. Thus, the inter-individual variation in insulin signaling mediated by IRS1 may play a plausible role in the development of colorectal cancer.
Source : Sf9 insect cells using baculovirus.
Sequence : 600-1245.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : IRS1 insulin receptor substrate 1 [ Homo sapiens ]
Synonyms : IRS1; insulin receptor substrate 1; HIRS-1; IRS-1
Gene ID : 3667
mRNA Refseq : NM_005544
Protein Refseq : NP_005535
MIM : 147545
UniProt ID : P35568
Chromosome Location : 2q36
Pathway : Adipocytokine signaling pathway; Insulin signaling pathway; Neurotrophin signaling pathway; Type II diabetes mellitus; Signaling by Insulin receptor; Signalling by NGF
Function : SH2 domain binding; insulin receptor binding; insulin-like growth factor receptor activity; insulin-like growth factor receptor binding; phosphoinositide 3-kinase binding; phosphoinositide 3-kinase binding; protein binding; protein kinase C binding; signal transducer activity; transmembrane receptor protein tyrosine kinase docking protein activity

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