Recombinant Human C4B C4B-26130TH

Recombinant Human C4B

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Recombinant Human C4B

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Cat.No. : C4B-26130TH
Product Overview : Recombinant fragment of Human C4b with N terminal proprietary tag, 36.63kDa.
Description : This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa inclusive of tags
Source : Wheat germ
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : VRSFFPENWLWRVET VDRFQILTLWLPDSL TTWEIHGLSLSKTKG LCVATPVQLRVFREF HLHLRLPMSVRRFEQ LELRPVLYNYLDKNL TVSVHVSPVE
Sequence Similarities : Contains 1 anaphylatoxin-like domain.Contains 1 NTR domain.
Gene Name : C4B complement component 4B (Chido blood group) [ Homo sapiens ]
Official Symbol : C4B
Synonyms : C4B; complement component 4B (Chido blood group); complement component 4B; complement C4-B; C4B1; C4B3; C4F; CH; CO4; CPAMD3;
Gene ID : 721
mRNA Refseq : NM_001002029
Protein Refseq : NP_001002029
MIM : 120820
Uniprot ID : P0C0L5
Chromosome Location : 6p21.3
Pathway : Complement Activation, Classical Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Pertussis, organism-specific biosystem; Pertussis, conserved biosystem;
Function : endopeptidase inhibitor activity;

Products Types

◆ Recombinant Protein

C4b-0053MRecombinant Mouse C4b Protein, GST-Tagged+Inquiry
C4B-0051HRecombinant Human C4B Protein, GST-Tagged+Inquiry
C4b-6785MRecombinant Mouse C4b protein, His-tagged+Inquiry
C4B-2587MRecombinant Mouse C4B Protein+Inquiry
C4b-7884MRecombinant Mouse C4b protein, His & T7-tagged+Inquiry

See All C4B Recombinant Protein

◆ Native Protein

C4B-1846HNative Human C4B Protein+Inquiry
C4B-99HNative Human C4b Binding Protein+Inquiry
C4B-10HNative Human C4B Protein+Inquiry

See All C4B Native Protein

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