Recombinant Human CDKN2C, GST-tagged CDKN2C-1475H

Recombinant Human CDKN2C, GST-tagged

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Recombinant Human CDKN2C, GST-tagged

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Cat. No. : CDKN2C-1475H
Product Overview : Recombinant full-length human p18INK4C was expressed inE. colicells using an N-terminal GST tag. MW = 42 kDa.
Description : p18INK4C is a member of the INK4 family of proteins that regulate the G1 to S cell cycle transition by binding to and inhibiting the pRb kinase activity of cyclin-dependent kinases 4 and 6. Mutation of p18INK4C impairs B-cell terminal differentiation and confers increased susceptibility to tumor development. p18INK4C can function as a tumor suppressor gene in Hodgkins lymphoma and its inactivation may contribute to the cell cycle deregulation and defective terminal differentiation characteristic of the Reed-Sternberg cells.
Source : E. coli.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 1bu9. :

Gene Name : CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) [ Homo sapiens ]
Synonyms : CDKN2C; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); p18; INK4C; p18-INK4C; cyclin-dependent kinase inhibitor 2C; CDK6 inhibitor p18; OTTHUMP00000009731; cyclin-dependent inhibitor; cyclin-dependent kinase 4 inhibitor C; cyclin-dependent kinase 6 inhibitor p18; CDKN6; OTTHUMP00000009730; OTTHUMP00000046546; p18-INK4c; p18-INK6; Cyclin-dependent kinase 6 inhibitor
Gene ID : 1031
mRNA Refseq : NM_001262
Protein Refseq : NP_001253
MIM : 603369
UniProt ID : P42773
Chromosome Location : 1p32
Pathway : Cell cycle
Function : cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding

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