Recombinant Human CDKN2D, GST-tagged CDKN2D-1476H

Recombinant Human CDKN2D, GST-tagged

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Recombinant Human CDKN2D, GST-tagged

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Cat. No. : CDKN2D-1476H
Product Overview : Recombinant full-length human p19INK4D was expressed inE. colicells using an N-terminal GST tag. MW = 44 kDa.
Description : p19INK4D protein is associated with CDK6 in several hematopoietic cell lines. It has been demonstrated that p19INK4D expression enhances cell survival under genotoxic conditions. By using p19INK4D-overexpressing cells, it has been demonstrated that p19INK4D expression correlates with the cellular resistance to UV treatment with increased DNA repair activity against UV-induced lesions. p19INK4D regulates protein network that integrate DNA repair, apoptosis and checkpoint mechanisms in order to maintain the genomic integrity.
Source : E. coli.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 1bd8. :

Gene Name : CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) [ Homo sapiens ]
Synonyms : CDKN2D; cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); p19; INK4D; p19-INK4D; cyclin-dependent kinase inhibitor 2D; CDK inhibitor p19INK4d; inhibitor of cyclin-dependent kinase 4d; cyclin-dependent kinase 4 inhibitor D p19; cell cycle inhibitor, Nur77 associating protein; Cyclin-dependent kinase 4 inhibitor D; p19-INK4d
Gene ID : 1032
mRNA Refseq : NM_001800
Protein Refseq : NP_001791
MIM : 600927
UniProt ID : P55273
Chromosome Location : 19p13
Pathway : Cell cycle
Function : cyclin-dependent protein kinase inhibitor activity; protein kinase binding

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