Recombinant Human K(lysine) Acetyltransferase 2B, GST-tagged

• Cat.No.: KAT2B-1481H
• Product Overview: Recombinant human PCAF (431-end) was expressed inE. colicells using a N-terminal GST tag. MW = 69 kDa.

Specification

• Cat. No.: KAT2B-1481H
• Description: PCAF is a protein that shows homology to the yeast GCN5 and associates with p300/CBP. PCAF has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. PCAF encodes a predicted 832-amino acid protein that showed by RNA blotting to be expressed in all tissues, most strongly in heart and skeletal muscle. PCAF has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. PCAF is required for MyoD activity and muscle differentiation. PCAF directly acetylated MyoD which then displays an increased affinity for its DNA target.
• Source: E. coli.
• Sequence: 431-end.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: KAT2B K(lysine) acetyltransferase 2B [ Homo sapiens ]
• Synonyms: KAT2B; K(lysine) acetyltransferase 2B; P; CAF; PCAF; P/CAF; CREBBP-associated factor; p300/CBP-associated factor; Histone acetyltransferase KAT2B; EC 2.3.1.48; Lysine acetyltransferase 2B; Histone acetylase PCAF; P300/CBP-associated factor; P/CAF; GCN5; GCN5L
• Gene ID: 8850
• mRNA Refseq: NM_003884
• Protein Refseq: NP_003875
• MIM: 602303
• UniProt ID: Q92831
• Chromosome Location: 3p24
• Pathway: Notch signaling pathway; Gene Expression; Transcription
• Function: histone acetyltransferase activity; histone deacetylase binding; transcription coactivator activity; transferase activity