Recombinant Human STAT5A, His-tagged

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Recombinant Human STAT5A, His-tagged

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Cat. No. : STAT5A-1498H
Product Overview : Recombinant full-length human STAT5 was expressed by baculovirus inSf9insect cells using an N-terminal His tag. MW = 92 kDa.
Description : STAT5 (signal transducers and activators of transcription 5) is a member of the STAT family and this protein is phosphorylated by receptor associated protein kinases in response to cytokines and growth factors. The differentiation of T helper (Th) cells is regulated by members of the STAT family of signaling molecules. In BCR-ABL-positive cells, STAT5 is constitutively activated by tyrosine phosphorylation. STAT5 activation results in upregulation of Bcl-XL and increased resistance to induction of apoptosis. STAT5 is involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6 beta-hydroxylase.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-lengt h.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDB rendering based on 1y1u. :

Gene Name : STAT5A signal transducer and activator of transcription 5A [ Homo sapiens ]
Synonyms : STAT5A; signal transducer and activator of transcription 5A; MGF; STAT5; STAT5
Gene ID : 6776
mRNA Refseq : NM_003152
Protein Refseq : NP_003143
MIM : 601511
UniProt ID : P42229
Chromosome Location : 17q11.2
Pathway : Acute myeloid leukemia; Chronic myeloid leukemia; ErbB signaling pathway; Jak-STAT signaling pathway; Pathways in cancer
Function : calcium ion binding; phosphate binding; protein binding; signal transducer activity; transcription factor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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