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Recombinant Human CDC42, T7 -tagged

Cat.No. : CDC42-26651TH
Product Overview : Recombinant full length mature human CDC42 fused to T7 tag at N-terminus; amino acids 1-188 , 22.4kDa.
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Description : The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
Conjugation : T7
Source : E. coli
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 2mM EDTA, 1mM DTT, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MASMTGGQQM GRGSHMQTIK CVVVGDGAVG KTCLLISYTT NKFPSEYVPT VFDNYAVTVM IGGEPYTLGL FDTAGQEDYD RLRPLSYPQT DVFLVCFSVV SPSSFENVKE KWVPEITHHC PKTPFLLVGT QIDLRDDPST IEKLAKNKQK PITPETAEKL ARDLKAVKYV ECSALTQKGL KNVFDEAILA ALEPPEPKKS RRC
Sequence Similarities : Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
Gene Name : CDC42 cell division cycle 42 (GTP binding protein, 25kDa) [ Homo sapiens ]
Official Symbol : CDC42
Synonyms : CDC42; cell division cycle 42 (GTP binding protein, 25kDa); cell division cycle 42 (GTP binding protein, 25kD); cell division control protein 42 homolog; CDC42Hs; G25K;
Gene ID : 998
mRNA Refseq : NM_001039802
Protein Refseq : NP_001034891
MIM : 116952
Uniprot ID : P60953
Chromosome Location : 1p36.1
Function : GTP binding; GTP-dependent protein binding; GTPase activity; GTPase activity; mitogen-activated protein kinase kinase kinase binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does CDC42 regulate cytoskeletal reorganization and cell morphology changes? 02/11/2022

CDC42 controls cytoskeletal dynamics, leading to changes in cell shape and movement.

What is the impact of CDC42 on neuronal development and synaptic plasticity? 06/13/2019

CDC42 is important in neuronal development and plays a role in forming and remodeling synaptic connections.

How do alterations in CDC42 expression or activity affect aging and age-related diseases? 12/08/2018

Changes in CDC42 activity can impact aging processes and contribute to the development of age-related diseases.

How does CDC42 contribute to cancer cell migration, invasion, and metastasis? 10/30/2018

CDC42 facilitates cancer progression by enhancing cell migration, invasion, and metastatic potential.

How does CDC42 influence wound healing and tissue regeneration? 08/06/2018

CDC42 aids in wound healing and regeneration by guiding cell migration and tissue restructuring.

What role does CDC42 play in the process of cell division and cell cycle regulation? 07/14/2018

CDC42 is crucial for cell division and cycle progression, coordinating cellular events for proper division.

What are the mechanisms by which CDC42 modulates immune cell trafficking and activation? 07/02/2018

CDC42 regulates immune cell movement and activation, essential for immune response and surveillance.

Customer Reviews (3)

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Reviews
03/28/2021

    Reliable protein crystallography, essential for structural studies.

    09/08/2019

      Exceptional protein engineering services, meets our lab's needs.

      05/01/2018

        Efficient peptide synthesis, crucial for our peptide research.

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