||Recombinant fragment, corresponding to amino acids 10-334 of Human JAB1 with N terminal His tag; 325 amino acids, 43kDa.
||The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation ofcyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
||Lyophilised:Reconstitute with 104 μl aqua dest.
||Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
||Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||QKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDH HYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDG ETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQV GRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPF VAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEY QTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWN KYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLG RGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLM SQVIKDKLFNQINIS
||Belongs to the peptidase M67A family. CSN5 subfamily.Contains 1 MPN (JAB/Mov34) domain.