| Description : |
The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. |
| Conjugation : |
Fc |
| Tissue specificity : |
One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U937 cells. Isoform GSCFR-3 is highly exp |
| Biological activity : |
The ED50 of CSF3R-27467TH is typically 2-3 ng/ml as measured by its ability to neutralize GCSF mediated proliferation of the murine myeloblastic m-NFS-60 cell line. |
| Form : |
Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not reco |
| Purity : |
>95% by SDS-PAGE |
| Storage buffer : |
Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin |
| Storage : |
Store at +4°C. |
| Sequences of amino acids : |
Theoretical Sequence: ECGHISVSAPIVHLGDPITASCIIK QNCSHLDPEPQIL WRLGAELQPGGRQQRLSDGTQESII TLPHLNHTQAFLS CCLNWGNSLQILDQVELRAGYPPAI PHNLSCLMNLTTS SLICQWEPGPETHLPTSFTLKSFKS RGNCQTQGDSILD CVPKDGQSHCCIPRKHLLLYQNMGI WVQAENALGTSMSPQLCLDPMDVVK LEPPMLRTMDPSPEAAPPQAGCLQL CWE PWQPGLHINQKCELRHKPQRGEASW ALVGPLPLEALQY ELCGLLPATAYTLQIRCIRWPLPGH WSDWSPSLELRTT ERAPTVRLDTWWRQRQLDPRTVQLF WKPVPLEEDSGRI QGYVVSWRPSGQAGAILPLCNTTEL SCTFHLPSEAQEVALVAYNSAGTSR PTPVVFSESRGPALTRLHAMARDPH SLW VGWEPPNPWPQGYVIEWGLGPPSAS NSNKTWRMEQNGR ATGFLLKENIRPFQLYEIIVTPLYQ DTMGPSQHVYAYS QEMAPSHAPELHLKHIGKTWAQLEW VPEPPELGKSPLT HYTIFWTNAQNQSFSAILNASSRGF VLHGLEPASLYHIHLMAASQAGATN STVLTLMTLTPRSSNTKVDKKVEPK SCD KTHTCPPCPAPELLGGPSVFLFPPK PKDTLMISRTPEV TCVVVDVSHEDPEVKFNWYVDGVEV HNAKTKPREEQYN STYRVVSVLTVLHQDWLNGKEYKCK VSNKALPAPIEKT ISKAKGQPREPQVYTLPPSRDELTK NQVSLTCLVKGFYPSDIAVEWESNG QPENNYKTTPPVLDSDGSFFLYSKL TVD KSRWQQGNVFSCSVMHEALHNHYTQ KSLSLSPGK |
| Sequence Similarities : |
Belongs to the type I cytokine receptor family. Type 2 subfamily.Contains 5 fibronectin type-III domains.Contains 1 Ig-like C2-type (immunoglobulin-like) domain. |
