Active Native Human Cathepsin D protein
Cat.No. : | CTSD-26411TH |
Product Overview : | Native Human Cathepsin D protein purified from Human Liver. |
- Specification
- Gene Information
- Related Products
Description : | Cathepsin D is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node-negative and node-positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer's plaques. As cathepsin D activity is increased by cigarette smoke, the enzyme may contribute to lung tissue damage in smokers. |
Source : | Human Liver |
Species : | Human |
Form : | Lyophilized from 2 mM Na phosphate, pH 6.5. |
Bio-activity : | >=300 units per mg protein. |
Molecular Mass : | 42000 |
Purity : | >=95% by SDS-PAGE |
Unit Definition : | One unit is defined as the amount of enzyme that digests hemoglobin-releasing peptides which are soluble in 10% TCA. The reaction is measured by an increase of an A 280 of 1.0 per 60 minutes at 37centigrade . Substrate: acid denatured hemoglobin, pH 1.8 (0.2% in reaction mixture). Buffer: 100 mM formate, pH 3.3. |
Notes : | Prepared from tissue shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. |
Stability : | > 1 year |
Storage : | Store <= -20 centigrade |
Gene Name : | CTSD cathepsin D [ Homo sapiens ] |
Official Symbol : | CTSD |
Synonyms : | CTSD; cathepsin D; cathepsin D (lysosomal aspartyl protease) , CPSD; ceroid lipofuscinosis; neuronal 10; CLN10; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; CPSD; MGC2311; |
Gene ID : | 1509 |
mRNA Refseq : | NM_001909 |
Protein Refseq : | NP_001900 |
MIM : | 116840 |
UniProt ID : | P07339 |
Chromosome Location : | 11p15.5 |
Pathway : | Ceramide signaling pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; LKB1 signaling events, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem; |
Function : | aspartic-type endopeptidase activity; peptidase activity; |
Products Types
◆ Recombinant Protein | ||
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CTSD-2103H | Recombinant Human CTSD Protein, GST-tagged | +Inquiry |
CTSD-786H | Recombinant Human CTSD Protein, His-tagged | +Inquiry |
CTSD-2752H | Recombinant Human CTSD Protein, His (Fc)-Avi-tagged | +Inquiry |
CTSD-877H | Recombinant Human CTSD Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
CTSD-5325D | Active Native Human CTSD protein | +Inquiry |
CTSD-1648H | Active Native Human Cathepsin D | +Inquiry |
CTSD-189H | Active Native Human Cathepsin D | +Inquiry |
◆ Lysates | ||
CTSD-1735HCL | Recombinant Human CTSD cell lysate | +Inquiry |
CTSD-3023MCL | Recombinant Mouse CTSD cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0264 | Cathepsin D Inhibitor Screening Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThere is an association between CTSD proteins and cognitive function. In some neurodegenerative diseases, abnormal accumulation and deposition of CTSD proteins may affect neuronal signaling and synaptic function, leading to a decline in cognitive function.
In some neurodegenerative diseases, levels of the CTSD protein may change. For example, people with Alzheimer's disease may have elevated levels of the CTSD protein. These changes may help in the diagnosis of the disease and in the assessment of the course of the disease.
For people with cognitive decline, their CTSD protein levels can be assessed by a blood or cerebrospinal fluid sample. This evaluation can help doctors understand whether the cause of cognitive decline is related to a neurodegenerative disease.
It is currently no treatment that directly targets the CTSD protein. However, some medications can reduce symptoms of neurodegenerative diseases, such as cholinesterase inhibitors such as donepezil, which can increase acetylcholine levels in synapses, which can improve cognitive function.
People with Parkinson's disease may have reduced levels of the CTSD protein. This decrease may be associated with neuronal death and impaired synaptic function. In addition, CTSD protein may also be associated with motor symptoms in patients with Parkinson's disease.
CTSD proteins play a role in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. It may change in these diseases, leading to structural alterations and impaired signaling of neuronal synapses.
Customer Reviews (3)
Write a reviewGood at western-blot experiments.
In experiments, the biocompatibility performed well.
The experimental conditions are broad, and the experimental results are accurate and repeatable.
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