Recombinant Human DAPK1

• Cat.No.: DAPK1-27363TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-363 of Human DAP Kinase 1, expressed by baculovirus in Sf9 insect cells using an N-terminal enzyme tag.

Specification

• Description: Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death.DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
• Biological activity: Specific activity: 49 nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.Contains 10 ANK repeats.Contains 1 death domain.Contains 1 protein kinase domain.

Gene Information

• Gene Name: DAPK1 death-associated protein kinase 1 [ Homo sapiens ]
• Official Symbol: DAPK1
• Synonyms: DAPK1; death-associated protein kinase 1; DAPK
• Gene ID: 1612
• mRNA Refseq: NM_004938
• Protein Refseq: NP_004929
• MIM: 600831
• Uniprot ID: P53355
• Chromosome Location: 9q34.1
• Pathway: Apoptosis, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; IFN-gamma pathway, organism-specific biosystem; Pathways in cancer, organism-specific biosystem
• Function: ATP binding; calmodulin binding; nucleotide binding; protein binding; protein serine/threonine kinase activity