Recombinant Human DYRK1A
Cat.No. : | DYRK1A-26456TH |
Product Overview : | Recombinant fragment of Human DYRK1A protein with an N terminal proprietary tag; predicted mwt: 35.53 kDa inclusive of tag. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5 UTR or in the 3 coding region. These variants encode at least five different isoforms. |
Protein length : | 90 amino acids |
Molecular Weight : | 35.530kDa inclusive of tags |
Source : | Wheat germ |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | NQGNQAYQNRPVAANTLDFGQNGAM DVNLTVYSNPRQETGIAGHPTYQFS ANTGPAHYMTEGHLTMRQGADREES PMTGVCVQQSPVAS |
Gene Name : | DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A [ Homo sapiens ] |
Official Symbol : | DYRK1A |
Synonyms : | DYRK1A; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; DYRK, DYRK1, MNBH; dual specificity tyrosine-phosphorylation-regulated kinase 1A; |
Gene ID : | 1859 |
mRNA Refseq : | NM_001396 |
Protein Refseq : | NP_001387 |
MIM : | 600855 |
Uniprot ID : | Q13627 |
Chromosome Location : | 21q22.13 |
Pathway : | Cell Cycle, Mitotic, organism-specific biosystem; G0 and Early G1, organism-specific biosystem; Hedgehog Signaling Pathway, organism-specific biosystem; Mitotic G1-G1/S phases, organism-specific biosystem; |
Function : | ATP binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
DYRK1A-2981H | Active Recombinant Human DYRK1A Protein, GST-tagged | +Inquiry |
DYRK1A-2982H | Recombinant Human DYRK1A Protein, GST-tagged | +Inquiry |
DYRK1A-0398H | Recombinant Human DYRK1A Protein (S127-E485), Tag Free | +Inquiry |
DYRK1A-0399H | Recombinant Human DYRK1A Protein (S127-E485), His tagged | +Inquiry |
DYRK1A-1188R | Recombinant Rhesus Macaque DYRK1A Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
DYRK1A-6752HCL | Recombinant Human DYRK1A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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