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Recombinant Human Activin A Receptor, Type IIB

Cat. No.: ACVR2B-1586H
Description: Activin A receptor, type IIB, also known as ACVR2B, is a human gene.[1] ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. Activin type II receptors are highly conserved. Human, mouse and rat type II activin receptors share greater than 98% amino acid sequence homology. Recombinant soluble activin type II receptors bind activin with high affinity, and are potent activin antagonists.
Source: Sf 21 Insect Cells.
State Of Matter: Lyophilized.
Purity: >95% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Molecular Weight: The predicted molecular weight of Recombinant Human Act R-IIB is Mr 41 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55-60 kDa.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name: ACVR2B activin A receptor, type IIB [ Homo sapiens ]
Synonyms: ACVR2B; activin A receptor, type IIB; ACTRIIB; ActR-IIB; MGC116908; EC 2.7.11.30; Activin receptor type-2B; ACTR-IIB
Gene ID: 93
mRNA Refseq: NM_001106
Protein Refseq: NP_001097
MIM: 602730
UniProt ID: Q13705
Chromosome Location: 3p22
Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway; Signaling by BMP
Function: ATP binding; activin binding; activin receptor activity, type II; growth factor binding; manganese ion binding; nucleotide binding; protein serine/threonine/tyrosine kinase activity; transferase activity; receptor activity

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