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Recombinant Human EIF2AK3

Cat.No. : EIF2AK3-30644TH
Product Overview : Recombinant cytoplasmic domain of Human PERK (amino acids 563-1115) with N terminal proprietary tag; 552 amino acids, MWt 115kDa; Genbank Number:
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Description : The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Protein length : 554 amino acids
Molecular Weight : 115.000kDa inclusive of tags
Source : E. coli
Tissue specificity : Ubiquitous. A high level expression is seen in secretory tissues.
Biological activity : The specific activity of EIF2AK3-30644TH was determined to be 18 nmol/min/mg by activity assay.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : NKYDSVSGEANDSSWNDIKNSGYIS RYLTDFEPIQCLGRGGFGVVFEAKN KVDDCNYAIKRIRLPNRELAREKVM REVKALAKLEHPGIVRYFNAWLEAP PEKWQEKMDEIWLKDESTDWPLSSP SPMDAPSVKIRRMDPFATKEHIEII APSPQRSRSFSVGISCDQTSSSESQ FSPLEFSGMDHEDISESVDAAYNLQ DSCLTDCDVEDGTMDGNDEGHSFEL CPSEASPYVRSRERTSSSIVFEDSG CDNASSKEEPKTNRLHIGNHCANKL TAFKPTSSKSSSEATLSISPPRPTT LSLDLTKNTTEKLQPSSPKVYLYIQ MQLCRKENLKDWMNGRCTIEERERS VCLHIFLQIAEAVEFLHSKGLMHRD LKPSNIFFTMDDVVKVGDFGLVTAM DQDEEEQTVLTPMPAYARHTGQVGT KLYMSPEQIHGNSYSHKVDIFSLGL ILFELLYPFSTQMERVRTLTDVRNL KFPPLFTQKYPCEYVMVQDMLSPSP MERPEAINIIENAVFEDLDFPGKTV LRQRSRSLSSSGTKHSRQSNNSHSP LPSN
Sequence Similarities : Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.Contains 1 protein kinase domain.
Gene Name : EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 [ Homo sapiens ]
Official Symbol : EIF2AK3
Synonyms : EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3; PEK; PERK;
Gene ID : 9451
mRNA Refseq : NM_004836
Protein Refseq : NP_004827
MIM : 604032
Uniprot ID : Q9NZJ5
Chromosome Location : 2p12
Pathway : Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Diabetes pathways, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem;
Function : ATP binding; eukaryotic translation initiation factor 2alpha kinase activity; eukaryotic translation initiation factor 2alpha kinase activity; identical protein binding; nucleotide binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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