Recombinant Human Chemokine (C-C Motif) Ligand 2 CCL2-124H

Recombinant Human Chemokine (C-C Motif) Ligand 2

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Recombinant Human Chemokine (C-C Motif) Ligand 2

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Cat. No. : CCL2-124H
Description : Monocyte chemotactic protein-1 (MCP-1) is an essential chemokine produced predominantly by macrophages and endothelial cells and is a potent chemotactic factor for monocytes. It can induce the proliferation and activation of killer cells known as CHAK (CC-Chemokine-activated killer). MCP-1 is also a potent activator of human basophils, induces degranulation and the release of histamines. MCP-1 is involved in the pathogenesis of atherosclerosis and myocardial infarction.
Source : NSO Cells.
State Of Matter : Lyophilized.
Purity : >97% by SDS Page and analyzed by silver stain.
Endotoxin : <0.1 ng per 1 µg as determined by the LAL method.
Molecular Weight : The predicted molecular weight of Recombinant Human MCP-1 is Mr 35 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 70-95 kDa.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
PDB rendering based on 1dok. :

Gene Name : CCL2 chemokine (C-C motif) ligand 2 [ Homo sapiens ]
Synonyms : CCL2; chemokine (C-C motif) ligand 2; GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; MGC9434; SCYA2; SMC-CF; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; monocyte secretory protein JE; small inducible cytokine A2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; Monocyte secretory protein JE; Small-inducible cytokine A2
Gene ID : 6347
mRNA Refseq : NM_002982
Protein Refseq : NP_002973
MIM : 158105
UniProt ID : P13500
Chromosome Location : 17q11.2-q12
Pathway : Cytokine-cytokine receptor interaction; Chemokine signaling pathway
Function : CCR2 chemokine receptor binding; G-protein-coupled receptor binding; chemokine activity; heparin binding; signal transducer activity; protein kinase activity

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