Recombinant Human Chemokine (C-C Motif) Ligand 5
Cat.No. : | CCL5-125H |
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- Gene Information
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Cat. No. : | CCL5-125H |
Description : | RANTES also known as Chemokine (C-C motif) ligand 5 (CCL5), a CC-chemokine is an important mediators of the immune and inflammatory response. It is also a potent chemoattractant for T cells and eosinophils. RANTES is involved in many inflammatory diseases, for example, bronchial asthma, delayed-type hypersensitivity reactions, viral infections, arthritis, chronic eosinophilic pneumonia, and idiopathic interstitial pneumonia. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >90% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Molecular Weight : | The predicted molecular weight of Recombinant Human RANTES is Mr 34 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 85-105 kDa. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Gene Name : | CCL5 chemokine (C-C motif) ligand 5 [ Homo sapiens ] |
Synonyms : | CCL5; chemokine (C-C motif) ligand 5; SISd; beta-chemokine RANTES; EoCP; RANTES; TCP228; MGC17164; SCYA5; RANTES; TCP228; D17S136E; MGC17164; chemokine (C-C motif) ligand 5; regulated upon activation; normally T-expressed; and presumably secrete; presumably secreted; small inducible cytokine A5; small inducible cytokine A5 (RANTES); small inducible cytokine subfamily A (Cys-Cys); member 5; Small-inducible cytokine A5; Small-inducible cytokine A5; T cell-specific protein P228; Eosinophil-chemotactic cytokine; RANTES(3-68); RANTES(4-68); T-cell specific RANTES protein; T-cell-specific protein RANTES; SIS-delta |
Gene ID : | 6352 |
mRNA Refseq : | NM_002985 |
Protein Refseq : | NP_002976 |
MIM : | 187011 |
UniProt ID : | P13501 |
Chromosome Location : | 17q11.2-q12 |
Pathway : | Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; Prion diseases; Toll-like receptor signaling pathway; Signaling by GPCR |
Function : | chemoattractant activity; chemokine activity; signal transducer activity |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCCL5 inhibitors may be used to control inflammation in diseases like rheumatoid arthritis or as an adjuvant in cancer therapy.
CCL5-based immunotherapies are being explored to enhance the immune response against cancer cells.
It can serve as a biomarker for some diseases, but it is usually used in conjunction with other markers for more accurate diagnostics.
Elevated CCL5 levels are associated with inflammation and may be indicative of certain diseases such as rheumatoid arthritis or HIV infection.
Yes, there are ongoing efforts to develop therapies that modulate CCL5 activity, particularly in diseases involving inflammation.
Customer Reviews (3)
Write a reviewThis specificity enables precise quantification and characterization of CCL5 and its interactions with other molecules or proteins of interest.
Its exceptional performance, coupled with its ability to generate clear and precise protein bands, make it an indispensable tool in achieving accurate and reliable results.
The CCL5 protein exhibits a high degree of specificity in various assays, ensuring accurate and reliable results.
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