Cat.No.:	FAP-28897TH
Product Overview:	Recombinant fragment corresponding to amino acids 29-760 of Human Fibroblast activation protein, alpha with C terminal His tag expressed in a Baculovirus infected Sf9 cell expression system, 85.5 kDa.
Description:	The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
Conjugation:	HIS
Tissue specificity:	Fibroblast specific.
Biological activity:	Specific Activity: 10.2 pmol/min/μg.Assay Condition: 50 mM Tris-HCl (pH7.5), 10 mM MgCl2, 1 mM MnCl2, 5μM substrate (A-P-AMC), room temperature.
Form:	Liquid
Purity:	>90% by SDS-PAGE
Storage buffer:	Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
Storage:	Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities:	Belongs to the peptidase S9B family.

Gene Name:	FAP fibroblast activation protein, alpha [ Homo sapiens ]
Official Symbol:	FAP
Synonyms:	FAP; fibroblast activation protein, alpha; seprase; DPPIV;
Gene ID:	2191
mRNA Refseq:	NM_004460
Protein Refseq:	NP_004451
MIM:	600403
Uniprot ID:	Q12884
Chromosome Location:	2q23
Function:	dipeptidyl-peptidase activity; metalloendopeptidase activity; peptidase activity; protein binding; protein dimerization activity;

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