Recombinant Human FGF19 Protein, Fc-tagged

• Cat.No.: FGF19-28824TH
• Product Overview: Recombinant Human FGF19(aa 1-216) fused with the C-terminus the Fc portion of human IgG1 was expressed in HEK 293 cells.

Specification

• Description: FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.
• Source: HEK 293 cells
• Species: Human
• Tag: Fc
• Form: Lyophilized from 0.2μm-filtered solution in PBS, pH 7.2.
• Molecular Mass: ~50kDa (SDS-PAGE)
• Protein length: aa 1-216
• Endotoxin: <0.1EU/μg purified protein (LAL test; Lonza).
• Purity: ≥90% (SDS-PAGE)
• Stability: Stable for at least 6 months after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade.
• Storage: Short Term Storage +4 centigrade;
  Long Term Storage -20 centigrade;
  After reconstitution, prepare aliquots and store at -20 centigrade. Avoid freeze/thaw cycles.
• Reconstitution: Reconstitute in distilled water.

Gene Information

• Gene Name: FGF19 fibroblast growth factor 19 [ Homo sapiens ]
• Official Symbol: FGF19
• Synonyms: FGF19; fibroblast growth factor 19; FGF-19
• Gene ID: 9965
• mRNA Refseq: NM_005117
• Protein Refseq: NP_005108
• MIM: 603891
• UniProt ID: O95750

Reviews

01/14/2022

Top-notch protein quality! It's our go-to for reliable and reproducible results.

09/08/2020

This product simplifies our research. It's a reliable tool that we can count on.

05/11/2018

If you're in the lab, you need this product. It streamlines processes and is a lab necessity.

Q&As

How is FGF19 gene expression regulated, and what factors influence its secretion and activity in various tissues?

FGF19 expression is regulated by bile acids and other factors. Its secretion and activity are influenced by nutrient availability, signaling pathways, and interactions with bile acid receptors.

Can you discuss the potential therapeutic applications of targeting FGF19 in metabolic disorders, and what challenges exist in developing such interventions?

Targeting FGF19 holds therapeutic potential for metabolic disorders. Challenges include achieving tissue-specific effects and understanding the long-term consequences of manipulating FGF19 signaling.

Can you explain the role of FGF19 in the enterohepatic circulation of bile acids and its implications for metabolic health?

FGF19 regulates bile acid synthesis in the liver and influences the enterohepatic circulation, impacting metabolic health by modulating lipid and glucose metabolism.

What is the role of FGF19 in the regulation of gut hormone secretion, and how does this contribute to its effects on metabolic processes?

FGF19 influences gut hormone secretion, including the release of glucagon-like peptide-1 (GLP-1). This regulation contributes to its metabolic effects, such as enhanced insulin sensitivity and reduced food intake.

What is the significance of FGF19 in metabolic diseases, and how does dysregulation contribute to conditions like obesity and non-alcoholic fatty liver disease (NAFLD)?

Dysregulation of FGF19 is implicated in metabolic diseases, including obesity and NAFLD. Altered FGF19 signaling may contribute to aberrant bile acid and lipid metabolism in these conditions.