| Species : |
Human |
| Source : |
E.coli |
| Tag : |
His |
| Protein Length : |
1730-2639 a.a. |
| Description : |
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene. |
| Conjugation : |
HIS |
| Tissue specificity : |
Ubiquitous. |
| Form : |
Lyophilised:Reconstitute with 111 μl aqua dest. |
| Storage buffer : |
Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5 |
| Storage : |
Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : |
VTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPL VGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKV AQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPG SPLQFYVDYVNCGHVTAYGPGLTHGVVNKPATFTVNTK DAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHVPGSPFTARVTGDDSMRMSHLKVGSAA DIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHV GISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIG DASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLS IEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHCD LSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYC IRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGG AHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAV EGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASF AVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVR FIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDP GLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTID GPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAP QHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCS KAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLK DKGEYTLVVKWGDEHIPGSPYRVVVP |
| Sequence Similarities : |
Belongs to the filamin family.Contains 1 actin-binding domain.Contains 2 CH (calponin-homology) domains.Contains 24 filamin repeats. |
| Publications : |
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