Recombinant Human Cadherin 5, Type 2 (Vascular Endothelium), Fc-His

• Cat.No.: CDH5-1696H
• Product Overview: Recombinant Human Vascular endothelial-cadherin encoding the extracellular domain of human Vascular Endothelial (VE)-Cadherin (amino acid residues 1 - 593) was fused to the 6X his-tagged Fc region of human IgG1 via a polypeptide linker. The chimeric protein was expressed inNSO cells.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: His
• Protein Length: 1-593 a.a.
• Description: Vascular endothelial-cadherin (VE-Cadherin) also known as cadherin-5 is an endothelial specific, homophilic adhesion molecule located at the lateral cell surface. VE-Cadherin is crucial for the proper assembly of vascular structures and the maintenance of vascular integrity. It plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-cadherin is a positive and endothelial cell-specific regulator of transforming growth factor-beta (TGF-beta) signaling. Therefore, the reduction or inactivation of VE-cadherin may contribute to progression of diseases where TGF-beta signaling is impaired.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
• Molecular Weight: The predicted molecular weight of Recombinant Human VE-Cadherin is Mr 92 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 116 kDa.
• Formulation: 0.2 µm filtered and lyophilized from PBS.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: CDH5 cadherin 5, type 2 (vascular endothelium) [ Homo sapiens ]
• Synonyms: cadherin 5, type 2 (vascular endothelium); 7B4; CD144; FLJ17376; CDH5; cadherin 5, type 2; 7B4 antigen; VE-cadherin; cd144 antigen; endothelial-specific cadherin; vascular endothelial cadherin; cadherin 5, type 2, VE-cadherin (vascular epithelium) ; VE-cadherin; CD144 antigen; Vascular endothelial cadherin
• Gene ID: 1003
• mRNA Refseq: NM_001795
• Protein Refseq: NP_001786
• MIM: 601120
• UniProt ID: P33151
• Chromosome Location: 16q22.1
• Pathway: Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Cell junction organization; Cell-cell adhesion systems
• Function: RPTP-like protein binding; calcium ion binding; protein phosphatase binding; receptor binding