||Recombinant Human Vascular endothelial-cadherin encoding the extracellular domain of human Vascular Endothelial (VE)-Cadherin (amino acid residues 1 - 593) was fused to the 6X his-tagged Fc region of human IgG1 via a polypeptide linker. The chimeric protein was expressed inNSO cells.
||Vascular endothelial-cadherin (VE-Cadherin) also known as cadherin-5 is an endothelial specific, homophilic adhesion molecule located at the lateral cell surface. VE-Cadherin is crucial for the proper assembly of vascular structures and the maintenance of vascular integrity. It plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-cadherin is a positive and endothelial cell-specific regulator of transforming growth factor-beta (TGF-beta) signaling. Therefore, the reduction or inactivation of VE-cadherin may contribute to progression of diseases where TGF-beta signaling is impaired.
|State Of Matter:
||>95% by SDS Page and analyzed by silver stain.
||<0.1 ng per 1 µg as determined by the LAL method.
||The predicted molecular weight of Recombinant Human VE-Cadherin is Mr 92 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 116 kDa.
||0.2 µm filtered and lyophilized from PBS.
|Storage And Stability:
||This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.