Recombinant Human Cadherin 5, Type 2 (Vascular Endothelium), Fc-His


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Recombinant Human Cadherin 5, Type 2 (Vascular Endothelium), Fc-His

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Cat. No. : CDH5-1696H
Product Overview : Recombinant Human Vascular endothelial-cadherin encoding the extracellular domain of human Vascular Endothelial (VE)-Cadherin (amino acid residues 1 - 593) was fused to the 6X his-tagged Fc region of human IgG1 via a polypeptide linker. The chimeric protein was expressed inNSO cells.
Description : Vascular endothelial-cadherin (VE-Cadherin) also known as cadherin-5 is an endothelial specific, homophilic adhesion molecule located at the lateral cell surface. VE-Cadherin is crucial for the proper assembly of vascular structures and the maintenance of vascular integrity. It plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-cadherin is a positive and endothelial cell-specific regulator of transforming growth factor-beta (TGF-beta) signaling. Therefore, the reduction or inactivation of VE-cadherin may contribute to progression of diseases where TGF-beta signaling is impaired.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Endotoxin : <0.1 ng per 1 µg as determined by the LAL method.
Molecular Weight : The predicted molecular weight of Recombinant Human VE-Cadherin is Mr 92 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 116 kDa.
Formulation : 0.2 µm filtered and lyophilized from PBS.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name : CDH5 cadherin 5, type 2 (vascular endothelium) [ Homo sapiens ]
Synonyms : cadherin 5, type 2 (vascular endothelium); 7B4; CD144; FLJ17376; CDH5; cadherin 5, type 2; 7B4 antigen; VE-cadherin; cd144 antigen; endothelial-specific cadherin; vascular endothelial cadherin; cadherin 5, type 2, VE-cadherin (vascular epithelium) ; VE-cadherin; CD144 antigen; Vascular endothelial cadherin
Gene ID : 1003
mRNA Refseq : NM_001795
Protein Refseq : NP_001786
MIM : 601120
UniProt ID : P33151
Chromosome Location : 16q22.1
Pathway : Cell adhesion molecules (CAMs); Leukocyte transendothelial migration; Cell junction organization; Cell-cell adhesion systems
Function : RPTP-like protein binding; calcium ion binding; protein phosphatase binding; receptor binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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