Recombinant Human FLT4 FLT4-31719TH

Recombinant Human FLT4

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Recombinant Human FLT4

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Cat.No. : FLT4-31719TH
Product Overview : Recombinant fragment, produced in a Baculovirus expression system, corresponding to amino acids 798-1298 of Human VEGF Receptor 3, with a N terminal proprietary tag, 82 kDa,.
Description : This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.
Source : Baculovirus
Tissue specificity : Placenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain.
Biological activity : Specific Activity: 17 pmol/min/μg.Assay conditions: VEGFR3 was incubated with a substrate (Tyr peptide 4 for 1h at RT in 1Xkinase buffer supplemented with ATP. Developer solution was added to reaction and reaction was stopped after 1h of incubation at RT.
Form : Liquid
Purity : by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 138mM Sodium chloride, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.Contains 7 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.
Gene Name : FLT4 fms-related tyrosine kinase 4 [ Homo sapiens ]
Official Symbol : FLT4
Synonyms : FLT4; fms-related tyrosine kinase 4; vascular endothelial growth factor receptor 3; PCL; VEGFR3;
Gene ID : 2324
mRNA Refseq : NM_002020
Protein Refseq : NP_002011
MIM : 136352
Uniprot ID : P35916
Chromosome Location : 5q34-q35
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Focal adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem; Signal Transduction, organism-specific biosystem;
Function : ATP binding; growth factor binding; nucleotide binding; protein binding; protein phosphatase binding;

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