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Recombinant Human FMO1

Cat.No.: FMO1-27875TH
Product Overview: Recombinant full length protein (Human). Expressed in insect cells infected with recombinant baculovirus (Autographa californica) containing cDNA inserts for human FMO1.
Description: Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region.Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.
Tissue specificity: Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 100mM Potassium phosphate buffer, pH 7.4
Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities: Belongs to the FMO family.
Gene Name: FMO1 flavin containing monooxygenase 1 [ Homo sapiens ]
Official Symbol: FMO1
Synonyms: FMO1; flavin containing monooxygenase 1; dimethylaniline monooxygenase [N-oxide-forming] 1;
Gene ID: 2326
mRNA Refseq: NM_002021
Protein Refseq: NP_002012
MIM: 136130
Uniprot ID: Q01740
Chromosome Location: 1q24.3
Pathway: Biological oxidations, organism-specific biosystem; Drug metabolism - cytochrome P450, organism-specific biosystem; Drug metabolism - cytochrome P450, conserved biosystem; FMO oxidizes nucleophiles, organism-specific biosystem; Metabolism, organism-specific biosystem;
Function: NADP binding; flavin adenine dinucleotide binding; flavin-containing monooxygenase activity; flavin-containing monooxygenase activity; monooxygenase activity;

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