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Recombinant Human FOS, GST-tagged

Cat.No.: FOS-26602TH
Product Overview: Recombinant full-length human FOS was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.
Source: Sf9 insect cells using baculovirus
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass: ~78 kDa
Purity: >90%
Applications: Kinase Assay; Western Blot
Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.2 ug/ul
Gene Name: FOS FBJ murine osteosarcoma viral oncogene homolog [ Homo sapiens ]
Official Symbol: FOS
Synonyms: FOS; p55; AP-1; C-FOS; FBJ murine osteosarcoma viral oncogene homolog; proto-oncogene c-Fos; activator protein 1; cellular oncogene c-fos; G0/G1 switch regulatory protein 7; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)
Gene ID: 2353
mRNA Refseq: NM_005252
Protein Refseq: NP_005243
MIM: 164810
UniProt ID: P01100
Chromosome Location: 14q24.3
Pathway: ATF-2 transcription factor network; Activated TLR4 signalling; Activation of the AP-1 family of transcription factors
Function: R-SMAD binding; double-stranded DNA binding; sequence-specific DNA binding

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