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Recombinant Human FOS, GST-tagged

Cat.No. : FOS-26602TH
Product Overview : Recombinant full-length human FOS was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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  • Gene Information
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Description : The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.
Source : Sf9 insect cells using baculovirus
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass : ~78 kDa
Purity : >90%
Applications : Kinase Assay; Western Blot
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.2 ug/ul
Gene Name : FOS FBJ murine osteosarcoma viral oncogene homolog [ Homo sapiens ]
Official Symbol : FOS
Synonyms : FOS; p55; AP-1; C-FOS; FBJ murine osteosarcoma viral oncogene homolog; proto-oncogene c-Fos; activator protein 1; cellular oncogene c-fos; G0/G1 switch regulatory protein 7; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)
Gene ID : 2353
mRNA Refseq : NM_005252
Protein Refseq : NP_005243
MIM : 164810
UniProt ID : P01100
Chromosome Location : 14q24.3
Pathway : ATF-2 transcription factor network; Activated TLR4 signalling; Activation of the AP-1 family of transcription factors
Function : R-SMAD binding; double-stranded DNA binding; sequence-specific DNA binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can FOS protein be used as a prognostic marker in certain diseases? 08/27/2019

Elevated levels of FOS protein in specific diseases may serve as a prognostic marker, indicating disease severity and progression.

How does FOS protein contribute to understanding cellular responses to stimuli? 06/15/2018

FOS protein plays a crucial role in signaling pathways, providing insights into how cells respond to various stimuli, including stress and growth factors.

How does FOS protein influence gene expression in cells? 01/28/2018

FOS protein acts as a transcription factor, regulating the expression of genes involved in cell proliferation, differentiation, and survival.

How can FOS protein analysis assist in personalized medicine approaches? 01/28/2017

FOS protein analysis can provide valuable information for tailoring treatment strategies based on the individual's molecular profile, contributing to personalized medicine.

What are the challenges associated with targeting FOS protein for therapeutic interventions? 09/17/2016

Targeting FOS protein for therapeutic purposes can be challenging due to its involvement in various cellular processes, requiring precise modulation.

Customer Reviews (3)

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Reviews
11/14/2022

    Its reliability and high quality make it a valuable tool in various applications, ranging from enzymatic assays to studying protein-protein interactions.

    10/22/2020

      The FOS protein is highly regarded for its excellent performance in WB assays and its significant contribution to protein EM structure analysis.

      02/22/2019

        The FOS protein is highly recommended for researchers conducting protein studies, especially in Western blotting (WB) experiments.

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