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Native Human FTH1

Cat.No.: FTH1-28155TH
Product Overview: Full length native Human Ferritin from Human spleen. MWt 450kDa consisting of 24 subunits, light chain 199 kDa, heavy chain 210 kDa. Amino acids 174 , 183.
Description: This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
Molecular Weight: 450.000kDa
Form: Liquid
Storage buffer: Preservative: 0.09% Sodium AzideConstituents: 0.15M Sodium chloride, 0.05M PBS, pH 7.5
Storage: Store at +4°C.
Sequence Similarities: Belongs to the ferritin family.Contains 1 ferritin-like diiron domain.
Gene Name: FTH1 ferritin, heavy polypeptide 1 [ Homo sapiens ]
Official Symbol: FTH1
Synonyms: FTH1; ferritin, heavy polypeptide 1; FTHL6; ferritin heavy chain; apoferritin; FHC; FTH; PIG15; placenta immunoregulatory factor; PLIF; proliferation inducing protein 15;
Gene ID: 2495
mRNA Refseq: NM_002032
Protein Refseq: NP_002023
Uniprot ID: P02794
Chromosome Location: 11q13
Pathway: Clathrin derived vesicle budding, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem; Membrane Trafficking, organism-specific biosystem; Mineral absorption, organism-specific biosystem; Mineral absorption, conserved biosystem;
Function: ferric iron binding; ferroxidase activity; iron ion binding; oxidoreductase activity; protein binding;

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