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Recombinant Human FZD7

Cat.No. : FZD7-26288TH
Product Overview : Recombinant fragment of Human Frizzled 7 with a proprietary tag: predicted molecular weight 36.52 kDa.
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  • Gene Information
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Description : Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif.FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
Protein length : 99 amino acids
Molecular Weight : 36.520kDa inclusive of tags
Source : Wheat germ
Tissue specificity : High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.
Biological activity : This product is useful for Antibody Production and Protein Array
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Glutathione is reduced
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : GAGEICVGQNTSDGSGGPGGGPTAY PTAPYLPDLPFTALPPGASDGRGRP AFPFSCPRQLKVPPYLGYRFLGERD CGAPCEPGRANGLMYFKEEERRFA
Sequence Similarities : Belongs to the G-protein coupled receptor Fz/Smo family.Contains 1 FZ (frizzled) domain.
Gene Name : FZD7 frizzled family receptor 7 [ Homo sapiens ]
Official Symbol : FZD7
Synonyms : FZD7; frizzled family receptor 7; frizzled (Drosophila) homolog 7 , frizzled 7, seven transmembrane spanning receptor , frizzled homolog 7 (Drosophila); frizzled-7; FzE3;
Gene ID : 8324
mRNA Refseq : NM_003507
Protein Refseq : NP_003498
MIM : 603410
Uniprot ID : O75084
Chromosome Location : 2q33
Pathway : Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; HTLV-I infection, organism-specific biosystem;
Function : G-protein coupled receptor activity; PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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