Recombinant Human GALNT1 GALNT1-27304TH

Recombinant Human GALNT1

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Recombinant Human GALNT1

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Cat.No. : GALNT1-27304TH
Product Overview : Recombinant fragment of Human GALNT1 with N terminal proprietary tag. Predicted MW 34.65 kDa.
Description : This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature.
Protein length : 82 amino acids
Molecular Weight : 34.650kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Widely expressed. Expressed in all tissues tested.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : LPAGDVLEPVQKPHE GPGEMGKPVVIPKED QEKMKEMFKINQFNL MASEMIALNRSLPDV RLEGCKTKVYPDNLP TTSVVIV
Sequence Similarities : Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.Contains 1 ricin B-type lectin domain.
Gene Name : GALNT1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) [ Homo sapiens ]
Official Symbol : GALNT1
Synonyms : GALNT1; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1); polypeptide N-acetylgalactosaminyltransferase 1; GalNAc T1; protein UDP acetylgalactosaminyltransferase 1;
Gene ID : 2589
mRNA Refseq : NM_020474
Protein Refseq : NP_065207
MIM : 602273
Uniprot ID : Q10472
Chromosome Location : 18q12.1
Pathway : Metabolic pathways, organism-specific biosystem; Mucin type O-Glycan biosynthesis, organism-specific biosystem; Mucin type O-Glycan biosynthesis, conserved biosystem; O-glycan biosynthesis, mucin type core, organism-specific biosystem; O-glycan biosynthesis, mucin type core, conserved biosystem;
Function : manganese ion binding; polypeptide N-acetylgalactosaminyltransferase activity; sugar binding; transferase activity, transferring glycosyl groups;

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