"GCDH" Related Products

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Recombinant Human GCDH, His-tagged

Cat.No.: GCDH-27464TH
Product Overview: Recombinant full length Human GCDH , with N terminal His-tag; 415aa, 45.8kDa inclusive of tag;
Description: The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
Protein length: 394 amino acids
Conjugation: HIS
Molecular Weight: 45.800kDa inclusive of tags
Source: E. coli
Tissue specificity: Isoform 1 and isoform 2 are expressed in fibroblasts and liver.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 5mM DTT, 200mM Sodium chloride, 20mM Tris HCl, pH 8
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMRPEFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTASK
Sequence Similarities: Belongs to the acyl-CoA dehydrogenase family.
Gene Name: GCDH glutaryl-CoA dehydrogenase [ Homo sapiens ]
Official Symbol: GCDH
Synonyms: GCDH; glutaryl-CoA dehydrogenase; glutaryl Coenzyme A dehydrogenase; glutaryl-CoA dehydrogenase, mitochondrial; ACAD5;
Gene ID: 2639
mRNA Refseq: NM_000159
Protein Refseq: NP_000150
MIM: 608801
Uniprot ID: Q92947
Chromosome Location: 19p13.2
Pathway: Fatty Acid Beta Oxidation, organism-specific biosystem; Fatty acid metabolism, organism-specific biosystem; Fatty acid metabolism, conserved biosystem; Lysine catabolism, organism-specific biosystem; Lysine degradation, organism-specific biosystem;
Function: fatty-acyl-CoA binding; flavin adenine dinucleotide binding; glutaryl-CoA dehydrogenase activity;

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