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Recombinant Human GCDH, His-tagged

Cat.No. : GCDH-27464TH
Product Overview : Recombinant full length Human GCDH , with N terminal His-tag; 415aa, 45.8kDa inclusive of tag;
  • Specification
  • Gene Information
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Description : The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
Protein length : 394 amino acids
Conjugation : HIS
Molecular Weight : 45.800kDa inclusive of tags
Source : E. coli
Tissue specificity : Isoform 1 and isoform 2 are expressed in fibroblasts and liver.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 5mM DTT, 200mM Sodium chloride, 20mM Tris HCl, pH 8
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHHSSGLVPRGSHMRPEF DWQDPLVLEEQLTTDEILIRDTFRT YCQERLMPRILLANRNEVFHREIIS EMGELGVLGPTIKGYGCAGVSSVAY GLLARELERVDSGYRSAMSVQSSLV MHPIYAYGSEEQRQKYLPQLAKGEL LGCFGLTEPNSGSDPSSMETRAHYN SSNKSYTLNGTKTWITNSPMADLFV VWARCEDGCIRGFLLEKGMRGLSAP RIQGKFSLRASATGMIIMDGVEVPE ENVLPGASSLGGPFGCLNNARYGIA WGVLGASEFCLHTARQYALDRMQFG VPLARNQLIQKKLADMLTEITLGLH ACLQLGRLKDQDKAAPEMVSLLKRN NCGKALDIARQARDMLGGNGISDEY HVIRHAMNLEAVNTYEGTHDIHALI LGRAITGIQAFTASK
Sequence Similarities : Belongs to the acyl-CoA dehydrogenase family.
Gene Name : GCDH glutaryl-CoA dehydrogenase [ Homo sapiens ]
Official Symbol : GCDH
Synonyms : GCDH; glutaryl-CoA dehydrogenase; glutaryl Coenzyme A dehydrogenase; glutaryl-CoA dehydrogenase, mitochondrial; ACAD5;
Gene ID : 2639
mRNA Refseq : NM_000159
Protein Refseq : NP_000150
MIM : 608801
Uniprot ID : Q92947
Chromosome Location : 19p13.2
Pathway : Fatty Acid Beta Oxidation, organism-specific biosystem; Fatty acid metabolism, organism-specific biosystem; Fatty acid metabolism, conserved biosystem; Lysine catabolism, organism-specific biosystem; Lysine degradation, organism-specific biosystem;
Function : fatty-acyl-CoA binding; flavin adenine dinucleotide binding; glutaryl-CoA dehydrogenase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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