Recombinant Human GDF5
Cat.No. : | GDF5-27470TH |
Product Overview : | Recombinant fragment (Human): GDF-5 is a homodimer, non-glycosylated, polypeptide chain containing 2 x 117 amino acids and having a total MW of 26.8 kDa. To enable bacterial expression of GDF-5 the N-terminal sequence Ala-Pro-Leu-Thr was removed and the L |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. |
Molecular Weight : | 13.000kDa |
Source : | E. coli |
Tissue specificity : | Predominantly expressed in long bones during embryonic development. |
Form : | Lyophilised:Reconstitute the lyophilized GDF5 in sterile 20mM AcOH to not less than 100μg/ml, which can then be further diluted to other aqueous solutions. |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: None |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the TGF-beta family. |
Gene Name : | GDF5 growth differentiation factor 5 [ Homo sapiens ] |
Official Symbol : | GDF5 |
Synonyms : | GDF5; growth differentiation factor 5; growth/differentiation factor 5; BMP14; cartilage derived morphogenetic protein 1; CDMP1; |
Gene ID : | 8200 |
mRNA Refseq : | NM_000557 |
Protein Refseq : | NP_000548 |
MIM : | 601146 |
Uniprot ID : | P43026 |
Chromosome Location : | 20q11.2 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem; |
Function : | cytokine activity; growth factor activity; |
Products Types
◆ Recombinant Protein | ||
GDF5-049H | Active Recombinant Human GDF5 Protein | +Inquiry |
GDF5-105H | Recombinant Active Human Gdf5 Protein, His-tagged(C-ter) | +Inquiry |
GDF5-3521M | Recombinant Mouse GDF5 Protein, His (Fc)-Avi-tagged | +Inquiry |
GDF5-299H | Active Recombinant Human GDF5 Protein (Ala382-Arg501), C-His tagged, Animal-free, Carrier-free | +Inquiry |
GDF5-4827H | Recombinant Human GDF5 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
GDF5-5968HCL | Recombinant Human GDF5 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket