Recombinant Human GDF5 GDF5-27470TH

Recombinant Human GDF5


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Recombinant Human GDF5

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Cat.No. : GDF5-27470TH
Product Overview : Recombinant fragment (Human): GDF-5 is a homodimer, non-glycosylated, polypeptide chain containing 2 x 117 amino acids and having a total MW of 26.8 kDa. To enable bacterial expression of GDF-5 the N-terminal sequence Ala-Pro-Leu-Thr was removed and the L
Description : The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
Molecular Weight : 13.000kDa
Source : E. coli
Tissue specificity : Predominantly expressed in long bones during embryonic development.
Form : Lyophilised:Reconstitute the lyophilized GDF5 in sterile 20mM AcOH to not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: None
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the TGF-beta family.
Gene Name : GDF5 growth differentiation factor 5 [ Homo sapiens ]
Official Symbol : GDF5
Synonyms : GDF5; growth differentiation factor 5; growth/differentiation factor 5; BMP14; cartilage derived morphogenetic protein 1; CDMP1;
Gene ID : 8200
mRNA Refseq : NM_000557
Protein Refseq : NP_000548
MIM : 601146
Uniprot ID : P43026
Chromosome Location : 20q11.2
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem;
Function : cytokine activity; growth factor activity;

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