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Recombinant Human GLO1

Cat.No. : GLO1-29068TH
Product Overview : Recombinant full length Human GLO1; amino acids 1-184 , 20.7kDa.
  • Specification
  • Gene Information
  • Related Products
Description : The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione.Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere.
Source : E. coli
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MAEPQPPSGG LTDEAALSCC SDADPSTKDF LLQQTMLRVK DPKKSLDFYT RVLGMTLIQK CDFPIMKFSL YFLAYEDKND IPKEKDEKIA WALSRKATLE LTHNWGTEDD ETQSYHNGNS DPRGFGHIGI AVPDVYSACK RFEELGVKFV KKPDDGKMKG LAFIQDPDGY WIEILNPNKM ATLM
Sequence Similarities : Belongs to the glyoxalase I family.
Gene Name : GLO1 glyoxalase I [ Homo sapiens ]
Official Symbol : GLO1
Synonyms : GLO1; glyoxalase I; lactoylglutathione lyase; GLOD1; glyoxalase domain containing 1;
Gene ID : 2739
mRNA Refseq : NM_006708
Protein Refseq : NP_006699
MIM : 138750
Uniprot ID : Q04760
Chromosome Location : 6p21.3-p21.1
Pathway : Pyruvate metabolism, organism-specific biosystem; Pyruvate metabolism, conserved biosystem;
Function : lactoylglutathione lyase activity; lyase activity; metal ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does GLO1 play in the pathogenesis of diabetes and related metabolic disorders? 02/27/2021

GLO1 is implicated in diabetes and metabolic disorders, influencing glycation end products and insulin signaling.

What are the mechanisms by which GLO1 modulates cancer cell proliferation and metastasis? 09/18/2019

GLO1 modulates cancer cell growth and spread, affecting tumor development and metastasis.

How does GLO1 interact with other components of the glyoxalase system in maintaining cellular homeostasis? 04/10/2019

GLO1 works with the glyoxalase system to regulate cellular detoxification and protect against metabolic stress.

How does GLO1 expression influence cellular oxidative stress and aging? 03/24/2019

GLO1 expression affects cellular oxidative stress, playing a role in aging and age-related cellular damage.

How do genetic variations in the GLO1 gene affect its enzymatic activity and the susceptibility to chronic diseases? 12/25/2018

Genetic variations in GLO1 alter its activity, affecting disease risk and response to metabolic stress.

What is the impact of GLO1 overexpression or deficiency on neurological functions and neurodegenerative diseases? 06/25/2018

Changes in GLO1 levels impact neurological function and may contribute to the progression of neurodegenerative diseases.

How does GLO1 regulate the detoxification of methylglyoxal and other reactive aldehydes in cells? 04/01/2018

GLO1 detoxifies methylglyoxal and other aldehydes, preventing cellular damage and maintaining metabolic balance.

Customer Reviews (3)

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Reviews
06/28/2022

    Timely protein expression optimization; improves our research efficiency.

    07/20/2020

      Accurate protein structural analysis; crucial for our studies.

      11/05/2019

        Dependable antibody validation; boosts our immunoprecipitation studies.

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