Recombinant Human Ephrin-A5 EFNA5-1611H

Recombinant Human Ephrin-A5

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Recombinant Human Ephrin-A5

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Cat. No. : EFNA5-1611H
Description : Ephrin-A5, also known as EFNA5, is a member of the ephrin gene family that prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin-A5 is required for the proper guidance and mapping of retinal axons in the mammalian midbrain.
Source : NSO cells.
Molecular Weight : The predicted molecular weight of Recombinant Human Ephrin-A5 is 48.6 kDa. However, the actual molecular weight as observed by migration on SDS Page is 50-55 kDa.
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Storage : This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
PDB rendering based on 1shw. :

Gene Name : EFNA5 ephrin-A5 [ Homo sapiens ]
Synonyms : EFNA5; ephrin-A5; AF1; EFL5; RAGS; EPLG7; GLC1M; LERK7 ; eph-related receptor tyrosine kinase ligand 7; LERK-7; AL-1; LERK-7; ephrin-A5
Gene ID : 1946
mRNA Refseq : NM_001962
Protein Refseq : NP_001953
MIM : 601535
UniProt ID : P52803
Chromosome Location : 5q21
Pathway : Axon guidance
Function : ephrin receptor binding

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